Telomeres, also known as the “protective caps” of our chromosomes, shorten with each cell
cycle due to the end replication problem. This process, termed telomere attrition, is …

Aging is characterized by a progressive decline in organism functions due to the impairment
of all organs. The deterioration of both proliferative tissues in liver, skin and the vascular …

Aging is a biological process that affects most cells, organisms and species. Human aging is
associated with increased susceptibility to a variety of chronic diseases, including …

Telomere dysfunction induces two types of cellular response: cellular senescence and
apoptosis. We analysed the extent to which the cellular level of telomere dysfunction and …

Aging is a complex biological process accompanied by a progressive decline in the physical
function of the organism and an increased risk of age-related chronic diseases such as …

Telomeres are unique DNA-protein structures that contain noncoding TTAGGG repeats and
telomere-associated proteins. These specialized structures are essential for maintaining …

Telomere attrition is considered a hallmark of ageing. Untangling the proximate causes of
telomere attrition may therefore reveal important aspects about the ageing process. In a …

Telomeres are regions of tandem arrays of TTAGGG repeats and associated proteins
located at chromosomal ends that allow cells to distinguish chromosome ends from double …

Abstract Telomeres form the ends of human chromosomes. Telomeres shorten with each
round of cell division and this mechanism limits proliferation of human cells to a finite …

Cellular senescence was first described by Hayflick and Moorhead in the 1960s as the
irreversible arrest of cells following prolonged cultivation. Telomere shortening is the key …