Abstract Selective cyclooxygenase (COX)-2 inhibitors (coxibs) were developed as one of the
anti-inflammatory drugs to avoid the various side effects of non-steroidal anti-inflammatory …

Nonsteroidal anti-inflammatory drugs (NSAIDs) are generally prescribed to ameliorate
symptoms associated with acute pain and chronic inflammatory diseases such as arthritis …

Nonsteroidal antiinflammatory drugs (NSAIDs) appear to reduce the risk of developing
cancer. One mechanism through which NSAIDs act to reduce carcinogenesis is to inhibit the …

A major goal in the area of cancer prevention and treatment is to make rational use of
defined molecular targets in order to block carcinogenesis. Studies conducted in …

Epidemiological observations and laboratory research have suggested that nonsteroidal
anti-inflammatory drugs (NSAIDs) reduce the risk of colon cancer and that the inhibition of …

Abstract Cyclooxygenase 2 (COX-2), also called prostaglandin endoperoxide synthase 2, is
involved in colorectal tumor development. This review deals with particular questions raised …

Arachidonic acid metabolism through cyclooxygenase (COX) pathways leads to the
generation of biologically active eicosanoids. Eicosanoid expression levels vary during …

Despite recent improvements in chemotherapy and radiation therapy in cancer management
with the addition of biological agents, novel treatment approaches are needed to further …

Cyclooxygenase (COX) catalyzes the conversion of arachidonic acid to prostaglandin H2.
The inducible isoform, COX-2, promotes colorectal tumorigenesis, and nonsteroidal anti …

Recent epidemiologic studies have shown a 40–50% reduction in mortality from colorectal
cancer in individuals who take nonsteroidal antiinflammatory drugs on a regular basis …