Abstract Background/Aims: Several clinical, epidemiological, and animal studies indicate
that nonsteroidal anti-inflammatory drugs (NSAIDs) may alter the incidence of colorectal …

BACKGROUND & AIMS: Multiple studies show that continuous use of nonsteroidal anti-
inflammatory drugs (NSAIDs) lowers the risk of colon cancer in humans and carcinogen …

There is now substantial evidence for the role of cyclooxygenase (COX)‐2 in causation and
prevention of cancer. Selective COX‐2 inhibitors (coxibs) were considered attractive …

Epidemiological and experimental studies have demonstrated the effect of non-steroidal anti-
inflammatory drugs (NSAIDs) in the prevention of human cancers. NSAIDs block …

A considerable amount of evidence collected from several different experimental systems
indicates that cyclooxygenase-2 (COX-2) may play a role in colorectal tumorigenesis. Large …

Evidence that chronic intake of non-steroidal anti-inflammatory drugs, especially aspirin,
prevents cancer development continues to accumulate. The data are particularly convincing …

Mortality in patients with advanced colorectal cancer (CRC) remains high. Epidemiologic
studies show that individuals taking nonselective, nonsteroidal anti-inflammatory drugs …

Increased prostaglandin (PG) production is associated with many inflammatory
pathophysiological conditions; it is derived from arachidonic acid by either of two enzymes …

The existing epidemiologic literature was comprehensively reviewed to retrieve all
epidemiologic studies (case control and cohort studies) that examined exposure to …

Background and aims. Discovery of an isoform of Cyclo-oxygenase (COX) 1, the inducible
COX-2, has made it possible to avoid some side effects of non-specific COX inhibitors. The …