Colorectal cancer (CRC) is one of the most common neoplasia in Western countries and the
second leading cause of cancer-related death. The vast majority of cases belong to sporadic …

Several types of human tumors overexpress cyclooxygenase (COX)-2 but not COX-1, and
gene knockout transfection experiments demonstrate a central role of COX-2 in …

The role of cyclooxygenase-2 (COX-2) in colorectal tumorigenesis in mice was studied by
Oshima et al. to determine the effects of COX-2 gene knockouts and a new COX-2 inhibitor …

Colorectal cancer is an excellent model for studying cancer prevention by means of
secondary (eg, polypectomy to remove a precursor adenoma) and primary …

The rate-limiting enzyme in arachidonate metabolism is mediated by enzymes known as
cyclooxygenases (COXs). These enzymes catalyze the biosynthesis of prostaglandin H 2 …

The finding that cyclooxygenase-2 (COX-2) is over-expressed and plays an important role in
carcinogenesis in gastrointestinal (GI) cancers including esophagus, gastric and colorectal …

Epidemiological and experimental studies indicate an inverse relationship between the risk
of colon cancer development and intake of aspirin and other nonsteroidal antiinflammatory …

Background Cyclooxygenase (COX) is the rate-limiting enzyme in the synthesis of
prostaglandins. It exists in two isoforms: COX-1 which is constitutively expressed and COX-2 …

Background Cyclo-oxygenase inhibition for the treatment of colorectal neoplasia has been
studied with renewed interest since the discovery of cyclo-oxygenase (Cox) 2 and the …

The limited success of current treatments for most advanced common malignancies
highlights the importance of cancer prevention. Clinical trials on cyclooxygenase (COX) …