Introduction Nonsteroidal anti-inflammatory drugs (NSAIDs) have been reported to have a
property to inhibit tumor development in some cancers while it shows various side effects …

Epidemiological studies have demonstrated that nonsteroidal anti-inflammatory drugs
(NSAIDs), known to inhibit cyclooxygenase (COX), reduce the risk of colorectal cancer. COX …

Chemoprevention represents a highly promising approach for the control of cancer. That
nonsteroidal anti-inflammatory drugs (NSAIDs) prevent colon and other cancers has led to …

Cyclooxygenase (COX) is a rate-limiting enzyme that catalyzes the conversion of
arachidonic acid, an essential fatty acid present in cell membrane phospholipids and …

In this review, we summarize studies that initiated further exploration of the relationship of
cyclooxygenase-2 (COX-2) to cancer, and evidence for COX-2 involvement in …

A large number of epidemiological studies have shown that regular use of aspirinor other
nonsteroidal anti-inflammatory drugs (NSAIDs) results in a 40–50% reduced risk of …

Evidence continues to accumulate that cyclooxygenase-2 (COX-2), an inducible COX
isoform, represents a potential pharmacological target for the prevention and treatment of …

An expanding body of evidence indicates that downregulation of the cy-clooxygenases (Cox-
1 and Cox-2) will be an important strategy for preventing cancer because cyclooxygenases …

Non‐steroidal anti‐inflammatory drugs (NSAIDs) and specific inhibitors of cyclooxygenase
(COX)‐2, are therapeutic groups widely used for the treatment of pain, inflammation and …

The positive association of decreased risk of colorectal cancer with nonsteroidal
antiinflammatory drug (NSAID) use, combined with the observation that cyclooxygenase …