Infections caused by malaria parasites place an enormous burden on the world's poorest
communities. Breakthrough drugs with novel mechanisms of action are urgently needed. As …

Highlights•Malaria remains a killer disease and drug resistance poses a growing
problem.•Aminoacyl tRNA synthetases (aaRSs) are essential housekeeping …

Aminoacyl transfer RNA (tRNA) synthetases (aaRSs) are attractive drug targets, and we
present class I and II aaRSs as previously unrecognized targets for adenosine 5 …

Malaria remains a major global health problem. Parasite resistance to existing drugs makes
development of new antimalarials an urgency. The protein synthesis machinery is an …

Background Treatment of parasitic diseases has been challenging due to evolution of drug
resistant parasites, and thus there is need to identify new class of drugs and drug targets …

Malaria is a parasitic illness caused by the genus Plasmodium from the apicomplexan
phylum. Five plasmodial species of P. falciparum (Pf), P. knowlesi, P. malariae, P. ovale, and …

Parasitic diseases result in considerable human morbidity and mortality. The continuous
emergence and spread of new drug-resistant parasite strains is an obstacle to controlling …

Background Plasmodium parasites are causative agents of malaria which affects> 500
million people and claims~ 2 million lives annually. The completion of Plasmodium genome …

Escalating drug resistance in malaria parasites and lack of vaccine entails the discovery of
novel drug targets and inhibitor molecules. The multi-component protein translation …

Malaria poses an enormous threat to human health. With ever increasing resistance to
currently deployed drugs, breakthrough compounds with novel mechanisms of action are …