Paracrine effects of FGF23 on the heart

M Leifheit-Nestler, D Haffner - Frontiers in endocrinology, 2018 - frontiersin.org
Fibroblast growth factor (FGF) 23 is a phosphaturic hormone primarily secreted by
osteocytes to maintain phosphate and mineral homeostasis. In patients with and without …

Direct and indirect effects of fibroblast growth factor 23 on the heart

T Nakano, H Kishimoto, M Tokumoto - Frontiers in endocrinology, 2023 - frontiersin.org
Fibroblast growth factor (FGF) 23 is a bone-derived phosphotropic hormone that regulates
phosphate and mineral homeostasis. Recent studies have provided evidence that a high …

FGF23 is a novel regulator of intracellular calcium and cardiac contractility in addition to cardiac hypertrophy

CD Touchberry, TM Green… - American Journal …, 2013 - journals.physiology.org
Fibroblast growth factor 23 (FGF23) is a hormone released primarily by osteocytes that
regulates phosphate and vitamin D metabolism. Recent observational studies in humans …

FGF23 in cardiovascular disease: innocent bystander or active mediator?

R Stöhr, A Schuh, GH Heine… - Frontiers in …, 2018 - frontiersin.org
Fibroblast growth factor− 23 (FGF23) is a mainly osteocytic hormone which increases renal
phosphate excretion and reduces calcitriol synthesis. These renal actions are mediated via …

FGF10 promotes cardiac repair through a dual cellular mechanism increasing cardiomyocyte renewal and inhibiting fibrosis

F Hubert, SM Payan, E Pelce, L Bouchard… - Cardiovascular …, 2022 - academic.oup.com
Aims Promoting cardiomyocyte renewal represents a major therapeutic approach for heart
regeneration and repair. Our study aims to investigate the relevance of FGF10 as a potential …

Cardiac actions of fibroblast growth factor 23

C Faul - Bone, 2017 - Elsevier
Fibroblast growth factors (FGF) are mitogenic signal mediators that induce cell proliferation
and survival. Although cardiac myocytes are post-mitotic, they have been shown to be able …

Biology of fibroblast growth factor 23: from physiology to pathology

M Courbebaisse, B Lanske - Cold Spring …, 2018 - perspectivesinmedicine.cshlp.org
Fibroblast growth factor (FGF) 23 is a phosphaturic hormone produced by osteocytes and
osteoblasts that binds to FGF receptors in the presence of the transmembrane protein …

FGF21 and cardiac physiopathology

A Planavila, I Redondo-Angulo… - Frontiers in …, 2015 - frontiersin.org
The heart is not traditionally considered either a target or a site of fibroblast growth factor-21
(FGF21) production. However, recent findings indicate that FGF21 can act as a …

Roles of FGF signals in heart development, health, and disease

N Itoh, H Ohta, Y Nakayama, M Konishi - Frontiers in cell and …, 2016 - frontiersin.org
The heart provides the body with oxygen and nutrients and assists in the removal of
metabolic waste through the blood vessels of the circulatory system. It is the first organ to …

FGF23/FGFR4-mediated left ventricular hypertrophy is reversible

A Grabner, K Schramm, N Silswal, M Hendrix… - Scientific reports, 2017 - nature.com
Fibroblast growth factor (FGF) 23 is a phosphaturic hormone that directly targets cardiac
myocytes via FGF receptor (FGFR) 4 thereby inducing hypertrophic myocyte growth and the …