Remote ischemic postconditioning: harnessing endogenous protection in a murine model of vascular cognitive impairment

MB Khan, MN Hoda, K Vaibhav, S Giri, P Wang… - Translational stroke …, 2015 - Springer
We previously reported that remote limb ischemic conditioning (RLIC; PERconditioning)
during acute stroke confers neuroprotection, possibly due to increased cerebral blood flow …

Remote limb ischemic conditioning during cerebral ischemia reduces infarct size through enhanced collateral circulation in murine focal cerebral ischemia

K Kitagawa, M Saitoh, K Ishizuka, S Shimizu - Journal of stroke and …, 2018 - Elsevier
Background Remote ischemic conditioning (RIC) induces protection in focal cerebral
ischemia. The conditioning is divided into pre-, per-, and postconditioning. However, the …

Chronic remote ischemic conditioning is cerebroprotective and induces vascular remodeling in a VCID model

MB Khan, S Hafez, MN Hoda, B Baban… - Translational Stroke …, 2018 - Springer
Vascular contributions to cognitive impairment and dementia (VCID) make up 50% of the
cases of dementia. The purpose of this study was to determine the effect of chronic remote …

[HTML][HTML] Limb ischemic perconditioning attenuates blood-brain barrier disruption by inhibiting activity of MMP-9 and occludin degradation after focal cerebral ischemia

C Ren, N Li, B Wang, Y Yang, J Gao, S Li… - Aging and …, 2015 - ncbi.nlm.nih.gov
Remote ischemic perconditioning (PerC) has been proved to have neuroprotective effects
on cerebral ischemia, however, the effect of PerC on the BBB disruption and underlying …

Short‐term remote ischemic conditioning may protect monkeys after ischemic stroke

L Guo, DA Zhou, DI Wu, J Ding, X He… - Annals of Clinical …, 2019 - Wiley Online Library
Objective We aimed to evaluate the safety and effectiveness of short‐term remote ischemic
postconditioning (RIPC) in acute stroke monkey models. Methods Acute stroke monkeys …

Limb remote ischemic per-conditioning in combination with post-conditioning reduces brain damage and promotes neuroglobin expression in the rat brain after …

C Ren, P Wang, B Wang, N Li, W Li… - Restorative …, 2015 - content.iospress.com
Purpose: Limb remote ischemic per-conditioning or post-conditioning has been shown to be
neuroprotective after cerebral ischemic stroke. However, the effect of combining remote per …

Exercise improves cerebral blood flow and functional outcomes in an experimental mouse model of vascular cognitive impairment and dementia (VCID)

MB Khan, H Alam, S Siddiqui, MF Shaikh… - Translational Stroke …, 2024 - Springer
Vascular cognitive impairment and dementia (VCID) are a growing threat to public health
without any known treatment. The bilateral common carotid artery stenosis (BCAS) mouse …

Remote limb ischemic postconditioning promotes motor function recovery in a rat model of ischemic stroke via the up‐regulation of endogenous tissue kallikrein

D Liang, XB He, Z Wang, C Li, BY Gao… - CNS neuroscience & …, 2018 - Wiley Online Library
Aims Remote ischemic conditionings, such as pre‐and per‐conditioning, are known to
provide cardioprotection in animal models of ischemia. However, little is known about the …

Remote ischaemic conditioning—a new paradigm of self-protection in the brain

DC Hess, RA Blauenfeldt, G Andersen… - Nature Reviews …, 2015 - nature.com
Remote ischaemic conditioning (RIC) triggers endogenous protective pathways in distant
organs such as the kidney, heart and brain, and represents an exciting new paradigm in …

Very delayed remote ischemic post-conditioning induces sustained neurological recovery by mechanisms involving enhanced angioneurogenesis and peripheral …

TR Doeppner, B Zechmeister, B Kaltwasser… - Frontiers in Cellular …, 2018 - frontiersin.org
Ischemic conditioning is defined as a transient and subcritical period of ischemia integrated
in an experimental paradigm that involves a stimulus of injurious ischemia, activating …