The KEAP1-NRF2 system: a thiol-based sensor-effector apparatus for maintaining redox homeostasis
M Yamamoto, TW Kensler… - Physiological …, 2018 - journals.physiology.org
The Kelch-like ECH-associated protein 1-NF-E2-related factor 2 (KEAP1-NRF2) system
forms the major node of cellular and organismal defense against oxidative and electrophilic …
forms the major node of cellular and organismal defense against oxidative and electrophilic …
Stress-sensing mechanisms and the physiological roles of the Keap1–Nrf2 system during cellular stress
T Suzuki, M Yamamoto - Journal of Biological Chemistry, 2017 - ASBMB
Transcription factor Nrf2 (NF-E2-related factor 2) is a master regulator of cellular responses
against environmental stresses. Nrf2 induces the expression of detoxification and …
against environmental stresses. Nrf2 induces the expression of detoxification and …
The Keap1–Nrf2 system as an in vivo sensor for electrophiles
A Uruno, H Motohashi - Nitric Oxide, 2011 - Elsevier
The Keap1–Nrf2 regulatory system plays a central role in cytoprotection from electrophilic
and oxidative stress. In unstressed conditions, Nrf2 is constantly ubiquitinated by the Cul3 …
and oxidative stress. In unstressed conditions, Nrf2 is constantly ubiquitinated by the Cul3 …
[HTML][HTML] Keap1, the cysteine-based mammalian intracellular sensor for electrophiles and oxidants
AT Dinkova-Kostova, RV Kostov, P Canning - Archives of biochemistry and …, 2017 - Elsevier
The Kelch-like ECH associated protein 1 (Keap1) is a component of a Cullin3-based Cullin-
RING E3 ubiquitin ligase (CRL) multisubunit protein complex. Within the CRL, homodimeric …
RING E3 ubiquitin ligase (CRL) multisubunit protein complex. Within the CRL, homodimeric …
Epigenetic regulation of Keap1-Nrf2 signaling
The kelch-like ECH-associated protein 1 (Keap1)-nuclear factor erythroid 2-related factor 2
(Nrf2) signaling axis serves as a “master regulator” in response to oxidative/electrophilic …
(Nrf2) signaling axis serves as a “master regulator” in response to oxidative/electrophilic …
KEAP1, a cysteine-based sensor and a drug target for the prevention and treatment of chronic disease
S Dayalan Naidu, AT Dinkova-Kostova - Open biology, 2020 - royalsocietypublishing.org
Redox imbalance and persistent inflammation are the underlying causes of most chronic
diseases. Mammalian cells have evolved elaborate mechanisms for restoring redox …
diseases. Mammalian cells have evolved elaborate mechanisms for restoring redox …
Roles of Nrf2 in cell proliferation and differentiation
S Murakami, H Motohashi - Free Radical Biology and Medicine, 2015 - Elsevier
Abstract The Keap1-Nrf2 system plays pivotal roles in defense mechanisms by regulating
cellular redox homeostasis. Nrf2 is an inducible transcription factor that activates a battery of …
cellular redox homeostasis. Nrf2 is an inducible transcription factor that activates a battery of …
The KEAP1-NRF2 system in healthy aging and longevity
D Matsumaru, H Motohashi - Antioxidants, 2021 - mdpi.com
Aging is inevitable, but the inherently and genetically programmed aging process is
markedly influenced by environmental factors. All organisms are constantly exposed to …
markedly influenced by environmental factors. All organisms are constantly exposed to …
Molecular mechanism of cellular oxidative stress sensing by Keap1
T Suzuki, A Muramatsu, R Saito, T Iso, T Shibata… - Cell reports, 2019 - cell.com
Summary The Keap1-Nrf2 system plays a central role in the oxidative stress response;
however, the identity of the reactive oxygen species sensor within Keap1 remains poorly …
however, the identity of the reactive oxygen species sensor within Keap1 remains poorly …
Molecular mechanism activating Nrf2–Keap1 pathway in regulation of adaptive response to electrophiles
K Itoh, KI Tong, M Yamamoto - Free Radical Biology and Medicine, 2004 - Elsevier
Electrophile responsive element (EpRE)-mediated gene induction is a pivotal mechanism of
cellular defense against the toxicity of electrophiles and reactive oxygen species (ROS) …
cellular defense against the toxicity of electrophiles and reactive oxygen species (ROS) …