We have studied the effect of NE 19550 (olvanil, N-(4-hydroxy-3-methoxyphenyl) methyl-9Z-
octadecenamide), a capsaicin analogue with approximately equipotent antinociceptive …

We have studied the effects of capsaicin, administered at concentrations found to be
antinociceptive in behavioural tests, on nociceptive responses evoked both in spinal dorsal …

1 Capsazepine has recently been described as a competitive capsaicin antagonist. We have
used this compound to test the hypotheses that the in vitro and in vivo effects of capsaicin …

1 We have tested the hypothesis that capsaicin‐induced activation, desensitization and
impairment of peripheral nociceptor function is mediated by separate mechanisms. This was …

Capsaicin was tested on peripheral fibres in vitro to determine whether evoked
depolarization or desensitization were likely to explain the antinociception observed after …

Capsaicin activates poorly myelinated primary afferent neurons, many of which are
polymodal nociceptors. Activation is accompanied by membrane depolarization and the …

Stimulation-produced modulation from the rostral, medial medulla (RMM) on the spinal
nociceptive tail-flick (TF) reflex and on lumbar spinal dorsal horn neuron reponses to …

When applied to peripheral fibres in a neonatal rat tail/spinal cord preparation in vitro,
capsaicin (0.2–50 μM) induced an activation, selective desensitization and reduced …

Intrathecal injections of capsaicin (CAP) and 4 other homovanillic acid (HMV) derivatives
related to the structure of CAP were carried out. Capsaicin, 1-nonenoylvanillylamide (NVA) …

Capsaicin produces pain by selectively activating polymodal nociceptive neurons. This
involves a membrane depolarization and the opening of a unique, cation-selective, ion …