Capsaicin stimulates neurokinin release in the spinal cord when applied both centrally and
peripherally. To determine whether these two actions have different mechanisms, we …

The acute and chronic effects of capsaicin on rat spinal dorsal horn neurons and the
excitatory transmission in the dorsal horn were investigated by means of intracellular …

1. The effects of electrical stimulation of cervical vagal afferent fibers on the nociceptive tail-
flick (TF) reflex and responses of spinal dorsal horn neurons to noxious cutaneous …

Results. At first we examined the nature of the stimulus produced by capsaicin. The tail of an
unanesthetized newborn rat (1-3 day old) was placed in the chamber as shown in Fig. 1 and …

An in vitro preparation for testing antinociceptive drugs is described. The preparation
consists of isolated spinal cord, spinal nerve roots and functionally connected tail of the …

The aim of this study was to investigate the analgesic effects of epidural opioids upon
persistent pain sensitivity in neonatal rat pups. Two models of persistent pain were used …

Recent work on the excitatory action of capsaicin on somatic and visceral afferent neurones
shows that depolarization is selective for C-fibre polymodal nociceptor afferents and …

Nociceptors, the subset of primary afferent neurons that detect pain-producing stimuli,
respond to a wide spectrum of physical and chemical stimuli that are potentially tissue …

Capsaicin selectively excites nociceptive primary afferent fibers and increases the frequency
of glutaminergic miniature excitatory postsynaptic currents (mEPSCs) in the substantia …

Purpose The current study was designed to examine the antinociceptive effect of
intrathecally administered capsaicin, a transient receptor potential vanilloid 1 receptor …