Efficient hydrolysis of amide bonds has long been a reaction of interest for organic chemists.
The rate constants of proteases are unmatched by those of any synthetic catalyst. It has …

The rates of hydrolysis by dilute acids of both a dissolved protein (egg albumin) and an
insoluble protein (wool) are shown to depend not only on the temperature and acidity but …

The mechanism of hydrolysis of O-acetylsalicylaldehyde has been established by isotopic
tracer studies of the reac-tion carried out in H2lsO. The hydrate of the aldehyde operates as …

The synthesis, characterization, and kinetic study of two linear pentapeptides l-threonyl-l-
alanyl-l-seryl-l-histidyl-l-aspartic acid (TASHD) and l-seryl-γ-aminobutyryl-l-histidyl-γ …

The hydrolysis of peptide‐amides in the solid state at 4° due to the presence of residual
strong acid was investigated. It was found that even small molar excesses of these acids …

Publisher Summary The peptide acids generated by protease-catalyzed hydrolysis of
proteins are generally good inhibitors of the enzymes that produce them. In the past few …

Peptides containing the aspartyl d-hydroxamic acid residue are cleaved specifically at the
carboxyl side of this residue at pH values> 6. The cleavage occurs by attack of both the …

Enzyme catalyzed formation of peptide bonds reached practical significance in partial
syntheses such as the conversion of pork insulin to human insulin. Catalysis is important …

An intramolecular-catalyzed cleavage of an aliphatic amide under biological conditions
(ambient temperature, neutral pH, absence of alien transition metals) was found to occur …

Publisher Summary Aza-amino acid residues are analogs of amino acids in which the α-CH
has been replaced by a nitrogen atom. This substitution has a profound effect on the …