Response from wang, humayun and taylor

G Wang, DE Taylor, MZ Humayun - Trends in Microbiology, 2000 - cell.com
We agree with Drs Achtman and Suerbaum that the high frequency of recombination plays a
major role in increasing polymorphism in Helicobacter pylori. However, it is obvious that …

Evolution of Helicobacter pylori: the role of recombination

S Suerbaum, M Achtman - Trends in microbiology, 1999 - cell.com
Helicobacter pylori is one of the most common pathogenic bacteria infecting humans. It is
estimated that more than half of the human population is chronically colonized with this …

Mutation and recombination in Helicobacter pylori: mechanisms and role in generating strain diversity

C Kraft, S Suerbaum - International journal of medical microbiology, 2005 - Elsevier
The pathogenic bacterium Helicobacter pylori infects half of the human population and it is
one of the most genetically diverse bacterial species known. The unusual combination of …

Genetic exchange

DA Israel - Helicobacter pylori: Physiology and Genetics, 2001 - Wiley Online Library
Helicobacter pylori has a recombinational, or panmictic, population structure, which is
indicative of frequent genetic exchange among strains. Horizontal gene exchange may …

Free recombination within Helicobacter pylori

S Suerbaum, JM Smith, K Bapumia… - Proceedings of the …, 1998 - National Acad Sciences
Sequences of three gene fragments (flaA, flaB, and vacA) from Helicobacter pylori strains
isolated from patients in Germany, Canada, and South Africa were analyzed for diversity and …

Characteristics of Helicobacter pylori natural transformation

DA Israel, AS Lou, MJ Blaser - FEMS microbiology letters, 2000 - academic.oup.com
For Helicobacter pylori, which exhibits substantial genetic diversity, many strains are
naturally competent for transformation by exogenous DNA. To better understand the …

Emergence of recombinant strains of Helicobacter pylori during human infection

D Kersulyte, H Chalkauskas, DE Berg - Molecular microbiology, 1999 - Wiley Online Library
Genetic recombination can be important evolutionarily in speeding the adaptation of
organisms to new environments and in purging deleterious mutations. Here, we describe …

Evidence for a Conjugation-Like Mechanism of DNA Transfer in Helicobacter pylori

EJ Kuipers, DA Israel, JG Kusters… - Journal of …, 1998 - Am Soc Microbiol
Many strains of Helicobacter pylori are naturally competent for transformation in vitro. Since
there is a high degree of genetic variation among H. pylori strains, we sought to determine …

[PDF][PDF] Genomic Changes during Chronic

D Falush, S Suerbaum, GD Niehus, P Correa, JG Fox - Helicobacter pylori, 2006 - Citeseer
The gastric pathogen Helicobacter pylori shows tremendous genetic variability within human
populations, both in gene content and at the sequence level. We investigated how this …

Restriction of DNA encoding selectable markers decreases the transformation efficiency of Helicobacter pylori

RJ Gorrell, J Yang, JG Kusters… - FEMS Immunology & …, 2005 - academic.oup.com
Helicobacter pylori populations recovered from the human stomach display extensive
recombination and quasispecies development, and this suggests frequent exchange of DNA …