Glucose metabolism is a mechanism by which energy is produced in form of adenosine
triphosphate (ATP) by mitochondria and precursor metabolites are supplied to enable the …

Pyruvate kinase is an enzyme that catalyzes the conversion of phosphoenolpyruvate and
ADP to pyruvate and ATP in glycolysis and plays a role in regulating cell metabolism. There …

Pyruvate kinase plays a pivotal role in regulating cell metabolism. The final and rate-limiting
step of glycolysis is the conversion of Phosphoenolpyruvate (PEP) to Pyruvate, which is …

Aerobic glycolysis is the dominant metabolic pathway utilized by cancer cells, owing to its
ability to divert glucose metabolites from ATP production towards the synthesis of cellular …

Glycolysis, a central metabolic pathway, harbors evolutionary conserved enzymes that
modulate and potentially shift the cellular metabolism on requirement. Pyruvate kinase …

Pyruvate kinase catalyzes the transfer of a high-energy phosphate group from phosphoenol
pyruvate (PEP) to generate pyruvate and ATP, a reaction that is the rate-limiting step of the …

Pyruvate kinase is a terminal enzyme in the glycolytic pathway, where it catalyzes the
conversion of phosphoenolpyruvate to pyruvate and production of ATP via substrate level …

Pyruvate kinase isoform M2 (PKM2) is a glycolysis enzyme catalyzing conversion of
phosphoenolpyruvate (PEP) to pyruvate by transferring a phosphate from PEP to ADP. We …

Originally identified as a metabolic enzyme that catalyzes the transfer of a phosphate group
from phosphoenolpyruvate (PEP) to ADP in the glycolytic pathway, pyruvate kinase M2-type …

PKM2, pyruvate kinase type M2, has been shown to play a key role in aerobic glycolysis and
to regulate the malignant behaviors of cancer cells. Recently, PKM2 has been revealed to …