Association of polymorphisms of the apolipoprotein (a) gene with lipoprotein (a) levels and myocardial infarction

SR Holmer, C Hengstenberg, HG Kraft, B Mayer… - Circulation, 2003 - Am Heart Assoc
Background—Serum lipoprotein (a)[Lp (a)] concentration is largely determined by variability
at the apolipoprotein (a) gene locus. Most prominent effects relate to polymorphisms in the …

[HTML][HTML] Genome-wide association study of plasma lipoprotein (a) levels identifies multiple genes on chromosome 6q [S]

C Ober, AS Nord, EE Thompson, L Pan, Z Tan… - Journal of lipid …, 2009 - ASBMB
Plasma lipoprotein (a)(Lp [a]) level is an independent risk factor of cardiovascular disease
that is under strong genetic control. We conducted a genome-wide association study of …

Frequent LPA KIV-2 Variants Lower Lipoprotein(a) Concentrations and Protect Against Coronary Artery Disease

JF Schachtl-Riess, A Kheirkhah, R Grüneis… - Journal of the American …, 2021 - jacc.org
Abstract Background Lipoprotein (a)(Lp (a)) concentrations are a major independent risk
factor for coronary artery disease (CAD) and are mainly determined by variation in LPA. Up …

Genetic variants associated with Lp (a) lipoprotein level and coronary disease

R Clarke, JF Peden, JC Hopewell… - … England Journal of …, 2009 - Mass Medical Soc
Background An increased level of Lp (a) lipoprotein has been identified as a risk factor for
coronary artery disease that is highly heritable. The genetic determinants of the Lp (a) …

Mechanisms of lipoprotein (a) pathogenicity: prothrombotic, proatherosclerotic, or both?

JD Spence, M Koschinsky - Arteriosclerosis, Thrombosis, and …, 2012 - Am Heart Assoc
(Arterioscler Thromb Vasc Biol. 2012; 32: 1550–1551.) angiographically, but carotid stenosis
(≥ 50%) was assessed by Doppler ultrasound, and peripheral vascular disease by …

Lipoprotein (a) as a potential causal genetic risk factor of cardiovascular disease: a rationale for increased efforts to understand its pathophysiology and develop …

S Tsimikas, JL Hall - Journal of the American College of Cardiology, 2012 - jacc.org
Recent published studies have provided increasing evidence that lipoprotein (a)[Lp (a)] may
be a potential causal, genetic, independent risk factor for cardiovascular disease (CVD). Lp …

Genetic evidence that lipoprotein (a) associates with atherosclerotic stenosis rather than venous thrombosis

PR Kamstrup, A Tybjærg-Hansen… - … , and vascular biology, 2012 - Am Heart Assoc
Objective—The aim of the present study was to determine whether lipoprotein (a)[Lp (a)],
considered a causal risk factor for cardiovascular disease, primarily promotes thrombosis or …

[HTML][HTML] Human genetics and the causal role of lipoprotein (a) for various diseases

F Kronenberg - Cardiovascular drugs and therapy, 2016 - Springer
Abstract Lipoprotein (a)[Lp (a)] is a highly atherogenic lipoprotein that is under strong
genetic control by the LPA gene locus. Genetic variants including a highly polymorphic copy …

[HTML][HTML] Lipoprotein (a): impact by ethnicity and environmental and medical conditions

B Enkhmaa, E Anuurad, L Berglund - Journal of lipid research, 2016 - ASBMB
Levels of lipoprotein (a)[Lp (a)], a complex between an LDL-like lipid moiety containing one
copy of apoB, and apo (a), a plasminogen-derived carbohydrate-rich hydrophilic protein, are …

Lipoprotein (a) an elusive cardiovascular risk factor

L Berglund, R Ramakrishnan - Arteriosclerosis, thrombosis, and …, 2004 - Am Heart Assoc
Lipoprotein (a)[Lp (a)], is present only in humans, Old World nonhuman primates, and the
European hedgehog. Lp (a) has many properties in common with low-density lipoprotein …