Lipoprotein (a): more interesting than ever after 50 years

JB Dubé, MB Boffa, RA Hegele… - Current opinion in …, 2012 - journals.lww.com
Despite the wealth of epidemiologic evidence supporting Lp (a) concentration as a CHD risk
factor, the lack of a definitive functional mechanism involving an Lp (a)-dependent pathway …

Lipoprotein (a): a genetic marker for cardiovascular disease and target for emerging therapies

A Cesaro, A Schiavo, E Moscarella… - Journal of …, 2021 - journals.lww.com
Abstract Lipoprotein (a)[Lp (a)] is an established cardiovascular risk factor, and growing
evidence indicates its causal association with atherosclerotic disease because of the …

Molecular basis of congenital lp (a) deficiency: a frequent apo (a)'null'mutation in caucasians

M Ogorelkova, A Gruber… - Human molecular …, 1999 - academic.oup.com
High plasma concentrations of lipoprotein (a)[Lp (a)], a covalent low-density lipoprotein-
apolipoprotein (a)[apo (a)] complex, are associated with coronary heart disease and stroke …

Lipoprotein (a)—the crossroads of atherosclerosis, atherothrombosis and inflammation

S Ugovšek, M Šebeštjen - Biomolecules, 2021 - mdpi.com
Increased lipoprotein (a)(Lp (a)) levels are an independent predictor of coronary artery
disease (CAD), degenerative aortic stenosis (DAS), and heart failure independent of CAD …

Impact of apolipoprotein (a) isoform size on lipoprotein (a) lowering in the HPS2-THRIVE study

S Parish, JC Hopewell, MR Hill… - Circulation: Genomic …, 2018 - Am Heart Assoc
Background: Genetic studies have shown lipoprotein (a)(Lp [a]) to be an important causal
risk factor for coronary disease. Apolipoprotein (a) isoform size is the chief determinant of Lp …

Single-Nucleotide Polymorphisms in LPA Explain Most of the Ancestry-Specific Variation in Lp(a) Levels in African Americans

RC Deo, JG Wilson, C Xing, K Lawson, WHL Kao… - PloS one, 2011 - journals.plos.org
Lipoprotein (a)(Lp (a)) is an important causal cardiovascular risk factor, with serum Lp (a)
levels predicting atherosclerotic heart disease and genetic determinants of Lp (a) levels …

Apolipoprotein (a) isoforms and the risk of vascular disease: systematic review of 40 studies involving 58,000 participants

S Erqou, A Thompson, E Di Angelantonio… - Journal of the American …, 2010 - jacc.org
Objectives: The purpose of this study was to assess the association of apolipoprotein
(a)(apo [a]) isoforms with cardiovascular disease risk. Background: Although circulating …

Lipoprotein (a): a genetic risk factor for premature coronary heart disease

AM Scanu - JAMA, 1992 - jamanetwork.com
Lipoprotein (a)(Lp [a]) can be defined as a lipoprotein particle having as a protein moiety
apolipoprotein B-100 (the protein associated with low-density lipoprotein) disulfide-linked to …

Ascertainment bias in the association between elevated lipoprotein (a) and familial hypercholesterolemia

M Trinder, ML DeCastro, H Azizi, L Cermakova… - Journal of the American …, 2020 - jacc.org
Background Lipoprotein (a) is an atherogenic low-density lipoprotein–like particle and
circulating levels are largely determined by genetics. Patients with familial …

Association of LPA variants with risk of coronary disease and the implications for lipoprotein (a)-lowering therapies: a Mendelian randomization analysis

S Burgess, BA Ference, JR Staley, DF Freitag… - JAMA …, 2018 - jamanetwork.com
Importance Human genetic studies have indicated that plasma lipoprotein (a)(Lp [a]) is
causally associated with the risk of coronary heart disease (CHD), but randomized trials of …