Genetic linkage between lipoprotein (a) phenotype and a DNA polymorphism in the plasminogen gene

DT Drayna, RA Hegele, PE Hass, M Emi, LL Wu… - Genomics, 1988 - Elsevier
Coronary heart disease risk correlates directly with plasma concentrations of lipoprotein
(a)(Lp (a)), a lowdensity lipoprotein-like particle distinguished by the presence of the …

Lipoprotein (a) levels and the risk of myocardial infarction among 7 ethnic groups

G Paré, A Çaku, M McQueen, SS Anand, E Enas… - Circulation, 2019 - Am Heart Assoc
Background: Lipoprotein (a)[Lp (a)] levels predict the risk of myocardial infarction (MI) in
populations of European ancestry; however, few data are available for other ethnic groups …

Ancestry, Lipoprotein(a), and Cardiovascular Risk Thresholds: JACC Review Topic of the Week

S Tsimikas, SM Marcovina - Journal of the American College of Cardiology, 2022 - jacc.org
This study reviews ancestral differences in the genetics of the LPA gene, risk categories of
elevated lipoprotein (a)[Lp (a)] as defined by guidelines, ancestry-specific Lp (a) risk …

Lipoprotein (a) and cardiovascular disease

PR Kamstrup - Clinical chemistry, 2021 - academic.oup.com
Background High lipoprotein (a) concentrations present in 10%–20% of the population have
long been linked to increased risk of ischemic cardiovascular disease. It is unclear whether …

[HTML][HTML] Daring to dream: Targeting lipoprotein (a) as a causal and risk-enhancing factor

ML Koschinsky, ESG Stroes, F Kronenberg - Pharmacological Research, 2023 - Elsevier
Abstract Lipoprotein (a)[Lp (a)], a distinct lipoprotein class, has become a major focus for
cardiovascular research. This review is written in light of the recent guideline and consensus …

A polymorphism in the protease-like domain of apolipoprotein (a) is associated with severe coronary artery disease

MM Luke, JP Kane, DM Liu, CM Rowland… - … , and vascular biology, 2007 - Am Heart Assoc
Objectives—The purpose of this study was to identify genetic variants associated with
severe coronary artery disease (CAD). Methods and Results—We used 3 case-control …

The apolipoprotein (a) kringle IV repeats which differ from the major repeat kringle are present in variably-sized isoforms

YY Hoek, ME Wittekoek, U Beisiegel… - Human molecular …, 1993 - academic.oup.com
Elevated levels of plasma lipoprotein (a)[Lp (a)] have been correlated with the development
of atherosclerosis in human populations. Apolipoprotein (a)[apo (a); the distinguishing …

Genetics of the quantitative Lp (a) lipoprotein trait: III. Contribution of Lp (a) glycoprotein phenotypes to normal lipid variation

E Boerwinkle, HJ Menzel, HG Kraft, G Utermann - Human genetics, 1989 - Springer
Summary Apolipoprotein (a)[apo (a)] is a large serum glycoprotein with several genetically
determined isoforms differing in their apparent molecular weight. We determined the effects …

Molecular definition of the extreme size polymorphism in apolipoprotein (a)

C Lackner, JC Cohen, HH Hobbs - Human molecular genetics, 1993 - academic.oup.com
Abstract Lipoprotein (a)[Lp (a)], an atherogenic lipoprotein, consists of an LDL particle
complexed with a large glycoprotein, apollpoprotein (a)[apo (a)]. Apo (a) is one of the most …

Lipoprotein (a) in homozygous familial hypercholesterolemia

HG Kraft, A Lingenhel, FJ Raal… - … , and vascular biology, 2000 - Am Heart Assoc
Lipoprotein (a)[Lp (a)] is a quantitative genetic trait that in the general population is largely
controlled by 1 major locus—the locus for the apolipoprotein (a)[apo (a)] gene. Sibpair …