The rising trends in asthma over the past 30 years are likely to be a consequence of
changes in the environment acting on a susceptible genotype. Recognising that …

Asthma was previously defined as an allergic Th2‐mediated inflammatory immune disorder.
Recently, this paradigm has been challenged because not all pathological changes …

Airway epithelial barrier dysfunction is frequently observed in asthma and may have
important implications. The physical barrier function of the airway epithelium is tightly …

Asthma is a global health problem with increasing prevalence. The airway epithelium is the
initial barrier against inhaled noxious agents or aeroallergens. In asthma, the airway …

The bronchial epithelium is the barrier to the external environment and plays a vital role in
protection of the internal milieu of the lung. It functions within the epithelial-mesenchymal …

Asthma is a chronic inflammatory airway disease characterized by variable airflow
obstruction in response to a wide range of exogenous stimuli. The airway epithelium is the …

The bronchial epithelium has a multifunctional role in the airway. It is actively engaged in
communicating with cells of the immune and inflammatory systems, as well as secreting …

Mucosal inflammation and more recently airway remodeling continue to be a focus of
interest when considering both the pathophysiology and treatment of asthma. Although a …

There has been great progress in identifying new asthma susceptibility genes. In asthmatic
subjects there is variable airway remodeling that includes features such as smooth muscle …

While asthma is an inflammatory disorder of the airways involving mediator release from
mast cells and eosinophils and orchestrated by T cells, inflammation alone is insufficient to …