Nickel is harmful to humans, being both carcinogenic and allergenic. However, the
mechanisms of this toxicity are still unresolved. We propose that Ni (II) ions disintegrate …

A combined pH-metric and spectroscopic (UV/vis, CD, NMR) study of the Ni (II) binding to
CH3CO-Thr-Glu-Ser-His-His-Lys-NH2 (AcTESHHKam), a blocked hexapeptide modeling a …

Nickel compounds are known human carcinogens, but the exact molecular mechanisms of
nickel carcinogenesis are not known. Due to their abundance, histones are likely targets for …

Ni (ii) ions are able to hydrolyze Naa-(Ser/Thr) peptide bonds in Naa-(Ser/Thr)-Xaa-His-Zaa
sequences. We found that various human transcription factors contain such nickel hydrolytic …

Nickel has been shown to be an essential trace element involved in the metabolism of
several species of bacteria, archea, and plants. In these organisms, nickel is involved in …

Ni (II) compounds are well known as human carcinogens, though the molecular events
which are responsible for this are not yet fully understood. It has been proposed that the …

Nickel is toxic to humans. Its compounds are carcinogenic. Furthermore, nickel allergy is a
severe health problem that affects approximately 10–20% of humans. The mechanism by …

Nickel (II) compounds are established human carcinogens, but the molecular mechanisms
underlying their activity are only partially known. One mechanism may include mediation by …

The molecular mechanism by which nickel carcinogenicity is exerted is not fully understood.
However, it is believed to involve DNA damage and epigenetic effects in chromatin, resulting …

We have demonstrated previously that Ni (II) binds to the C-terminal− TESHHKAKGK motif of
isolated bovine histone H2A. At physiological pH, the bound Ni (II) assists in hydrolysis of …