The majority of known nucleolar proteins are freely exchanged between the nucleolus and
the surrounding nucleoplasm. One way proteins are retained in the nucleoli is by the …

Metallochaperones are essential for the safe and targeted delivery of necessary yet toxic
metal cofactors to their respective protein partners. In this study we examine the nickel …

Following the discovery of the first specific and essential role of nickel in biology in 1975 (the
dinuclear active site of the enzyme urease)[1], nickel has become a major player in …

Nickel is a metallic element belonging to group VIII-B of the periodic table. It is resistant to
alkalis, but generally dissolves in dilute oxidizing acids. Nickel carbonate, nickel sulfide, and …

The intraceliular fate of particulate crystalline αNiS, an inducer of neoplastic transformation
which is readily phagocytized by cultured cells, was compared with that of particulate …

The amino terminal Cu (II)-and Ni (II)-binding (ATCUN) motif has been studied for more than
35 years. 1 During that time, our range of knowledge of the motif has expanded from a small …

Background In eukaryotic cells the nuclear envelope isolates and protects DNA from
molecules that could damage its structure or interfere with its processing. Moreover, selected …

This article describes data related to a research article titled “Comprehensive analysis of the
dynamic structure of nuclear localization signals” by Yamagishi et al.[1]. In this article, we …

A variety of nuclear localization signals (NLSs) are experimentally known although only one
motif was available for database searches through PROSITE. We initially collected a set of …

Biological environments present a complex array of metal-binding ligands. Metal-binding
proteins have been the overwhelming focus of study because of their important and well …