Benzyl-14C-labeled tripelennamine and its N-nitroso derivative (NDT) were administered
(20 mg/kg; 50 muc/kg ip) separately to control and phenobarbital-pretreated rats. Tissue …

Single intravenous injections of labelled dehydro ep iandrosterone sulphate (DS), de-hydro
epi nandrosterone (D), androstenedione (A) and testosterone (T) have been administered to …

Structural features which distinguish steroidal drugs from natural hormones often persist in
their metabolites. At the same time, the metabolic transformations of the drugs parallel, in …

The metabolic fate of medroxyprogesterone acetate (6α-methyl-17α-acetoxyprogesterone,
MAP) was studied in intact baboons and in those with bile fistulas. The steroid moiety was …

Th#{149} mthbollsm and excretion of 2-, 3-, and 4-nitrotoluene(2NT, 3NT, and 4NT,
respectlv&y) wrs studlsd in male Fischr 344 rats. Excreta were collected for 72 hr aftor an …

Studies in the rat of pregnanolone (3α-hydroxy-5β-pregnane-20-one), a pharmacologically
active metabolite of progesterone, indicated rapid transformation to more polar metabolites …

1 A gas‐liquid chromatography procedure for the determination of chlorphentermine (I), N‐
hydroxychlorphentermine (II) and alpha, alpha‐dimethyl‐alpha‐nitro‐beta‐(4‐chlorophenyl) …

The more polar of the two major urinary metabolites of methandrostenolone, 17β-hydroxy-17-
methyl-1, 4-androstadien-3-one, in man has already been identified as 6β …

The metabolism of methaqualone (2-methyl-3-o-tolyl-4 (3 H)-quinazolinone) has been
studied in man and the rat using gas phase analytical methods. Seven new metabolites …

1 Ethinyloestradiol was extensively metabolised in vitro by human jejunal mucosa to form
ethinyloestradiol sulphate. 2 The amount of conjugation was directly related to the weight of …