Translation of poly (A) tails leads to mRNA cleavage but the mechanism and global
pervasiveness of this “nonstop/no-go” decay process is not understood. Here we performed …

Co-translational mRNA degradation is a widespread process in which 5′–3′
exonucleolytic degradation follows the last translating ribosome, thus producing an in vivo …

Faulty or damaged messenger RNAs are detected by the cell when translating ribosomes
stall during elongation and trigger pathways of mRNA decay, nascent protein degradation …

Translation of problematic sequences in mRNAs leads to ribosome collisions that trigger a
series of quality control events including ribosome rescue, degradation of the stalled …

A poly (A) tail is found at the 3 end of nearly every fully processed eukaryotic mRNA and has
been suggested to influence virtually all aspects of mRNA metabolism. Its proposed …

It is generally assumed that mRNAs undergoing translation are protected from decay. Here,
we show that mRNAs are, in fact, co-translationally degraded. This is a widespread and …

The addition of poly (A) tails to eukaryotic nuclear mRNAs promotes their stability, export to
the cytoplasm and translation. Subsequently, the balance between exonucleolytic …

Histone mRNAs are rapidly degraded when DNA replication is inhibited during S phase with
degradation initiating with oligouridylation of the stem loop at the 3′ end. We developed a …

Poly (A) tail removal is often the initial and rate-limiting step in mRNA decay and is also
responsible for translational silencing of maternal mRNAs during oocyte maturation and …

The addition of poly (A)-tails to RNA is a process common to almost all organisms. In
eukaryotes, stable poly (A)-tails, important for mRNA stability and translation initiation, are …