Induction of apoptosis in liver tumors by the monoterpene perillyl alcohol

JJ Mills, RS Chari, IJ Boyer, MN Gould, RL Jirtle - Cancer research, 1995 - AACR
The monoterpenes d-limonene and perillyl alcohol (POH) inhibit the growth of mammary
tumors. In this investigation we tested whether POH is also effective in reducing liver tumor …

Perillyl alcohol-mediated inhibition of lung cancer cell line proliferation: potential mechanisms for its chemotherapeutic effects

M Xu, HS Floyd, SM Greth, WCL Chang… - Toxicology and applied …, 2004 - Elsevier
Perillyl alcohol (POH) is currently being tested in clinical trials as an anticancer agent,
though its mechanism of action has not been definitively established. We treated two human …

Phase I clinical trial of perillyl alcohol administered daily.

GH Ripple, MN Gould, JA Stewart, KD Tutsch… - Clinical cancer research …, 1998 - AACR
Abstract Perillyl alcohol (POH; NSC-641066), a naturally occurring monoterpene, has shown
antitumor and preventive activity in preclinical studies in rodent models. Drug-related …

Antitumorigenic effects of limonene and perillyl alcohol against pancreatic and breast cancer

PL Crowell, AS Ayoubi, YD Burke - Dietary phytochemicals in cancer …, 1996 - Springer
Perillyl alcohol is a natural product from cherries and other edible plants. Perillyl alcohol and
d-limonene, a closely related dietary monoterpene, have chemotherapeutic activity against …

Perillyl alcohol and perillic acid induced cell cycle arrest and apoptosis in non small cell lung cancer cells

L Yeruva, KJ Pierre, A Elegbede, RC Wang, SW Carper - Cancer letters, 2007 - Elsevier
Plant products such as perillyl alcohol have been reported to possess anti-tumor activities
against a number of human cancers though the mechanism of action has not yet been …

Mammary carcinoma regression induced by perillyl alcohol, a hydroxylated analog of limonene

JD Haag, MN Gould - Cancer chemotherapy and pharmacology, 1994 - Springer
The monoterpene perillyl alcohol has been shown to induce the regression of 81% of small
mammary carcinomas and up to 75% of advanced mammary carcinomas initiated by 7, 12 …

Chemotherapy of pancreatic cancer with the monoterpene perillyl alcohol

MJ Stark, YD Burke, JH McKinzie, AS Ayoubi… - Cancer letters, 1995 - Elsevier
Perillyl alcohol has antitumor activity against rat mammary and liver cancer. Here, we report
the chemotherapeutic effects of perillyl alcohol on pancreatic cancer. Perillyl alcohol …

Chemopreventive effect of perillyl alcohol on 4‐(methylnitrosamino)‐1‐(3‐pyridyl)‐1‐butanone induced tumorigenesis in (C3H/HeJ XA/J)F1 mouse lung

LE Lantry, Z Zhang, F Gao, KA Crist… - Journal of Cellular …, 1997 - Wiley Online Library
This study was designed to test the chemopreventive potential of perillyl alcohol, an inhibitor
of farnesyltransferase, in a mouse lung tumor bioassay. Perillyl alcohol is a naturally …

Inhibition by D‐limonene of experimental hepatocarcinogenesis in Sprague‐Dawley rats does not involve p21ras plasma membrane association

I Kaji, M Tatsuta, H Iishi, M Baba… - … journal of cancer, 2001 - Wiley Online Library
The effects of d‐limonene on hepatocarcinogenesis induced by N‐nitrosomorpholine (NNM)
and on membrane‐associated p21ras and labeling and apoptotic indices of the liver were …

Perillyl Alcohol Inhibits Human Breast Cancer Cell Growth in vitro and in vivo

T Yuri, N Danbara, M Tsujita-Kyutoku… - Breast cancer research …, 2004 - Springer
The effect of monoterpene perillyl alcohol (POH) on cell growth, cell cycle progression, and
expression of cell cycle-regulatory proteins in estrogen receptor (ER)-positive (KPL-1 and …