Alzheimer's disease (AD) is typified by a robust microglial-mediated inflammatory response
within the brain. Indeed, microglial accumulation around plaques in AD is one of the …

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by protein
aggregation in the brain. Recent studies have revealed the critical role of microglia in AD …

Introduction: Despite the revolutionary progress in neurodegenerative disease research,
there is no cure for Alzheimer's disease (AD). This is a chronic progressive …

Alzheimer's disease (AD) is characterized by three major histopathological hallmarks: β-
amyloid deposits, neurofibrillary tangles and gliosis. While neglected for decades, the …

Alzheimer's disease (AD) is one of the most common types of age-related dementia
worldwide. In addition to extracellular amyloid plaques and intracellular neurofibrillary …

Alzheimer's disease (AD) is a devastating chronic neurodegenerative disease with currently
no available disease modifying treatment. In recent years, the peptide amyloid-β has been …

Microglia are the resident macrophages of the central nervous system. They play key roles
in brain development, and physiology during life and aging. Equipped with a variety of …

Microglia are brain-resident myeloid cells that mediate key functions to support the CNS.
Microglia express a wide range of receptors that act as molecular sensors, which recognize …

Contrary to early views, we now know that systemic inflammatory/immune responses
transmit to the brain. The microglia, the resident “macrophages” of the brain's innate immune …

Microglia are emerging as key players in neurodegenerative diseases, such as Alzheimer's
disease (AD). Thus far, microglia have rather been known as modulator of …