Ganciclovir-resistant cytomegalovirus disease after allogeneic stem cell transplantation: pitfalls of phenotypic diagnosis by in vitro selection of an UL97 mutant strain

K Hamprecht, T Eckle, L Prix, C Faul… - The Journal of …, 2003 - academic.oup.com
A 9-month posttransplantation course of an allogeneic stem-cell transplant recipient (human
cytomegalovirus [HCMV] serostatus, donor positive/recipient negative), in whom ganciclovir …

GANCICLOVIR RESISTANCE AS A RESULT OF ORAL GANCICLOVIR IN A HEART TRANSPLANT RECIPIENT WITH MULTIPLE HUMAN CYTOMEGALOVIRUS …

F Baldanti, L Simoncini, A Sarasini, M Zavattoni… - …, 1998 - journals.lww.com
Background. The emergence of a ganciclovir (GCV)-resistant human cytomegalovirus
(HCMV) strain in a heart transplant recipient (HTR) coinfected by multiple HCMV strains was …

Lack of emergence of cytomegalovirus UL97 mutations conferring ganciclovir (GCV) resistance following preemptive GCV therapy in allogeneic stem cell transplant …

C Gilbert, J Roy, R Belanger, R Delage… - Antimicrobial agents …, 2001 - Am Soc Microbiol
Fifty allogeneic stem cell transplant recipients were enrolled in a prospective
cytomegalovirus pp65 antigenemia-guided preemptive therapy trial. Among these, 10 of 34 …

Human cytomegalovirus double resistance in a donor-positive/recipient-negative lung transplant patient with an impaired CD4-mediated specific immune response

F Baldanti, D Lilleri, G Campanini… - Journal of …, 2004 - academic.oup.com
Background: Emergence of human cytomegalovirus (HCMV) resistance to ganciclovir in
solid-organ transplant recipients has been found to be mostly associated with primary …

Cytomegalovirus drug resistance and clinical implications

SW Chou - Transplant Infectious Disease, 2001 - Wiley Online Library
Antiviral agents are commonly used for cytomegalovirus (CMV) prophylaxis or therapy after
solid organ transplantation. Until recently, the detection of drug‐resistant CMV in this setting …

Failure of ganciclovir treatment associated with selection of a ganciclovir-resistant cytomegalovirus strain in a lung transplant recipient

S Alain, P Honderlick, D Grenet, M Stern… - …, 1997 - journals.lww.com
We report the case of a lung transplant recipient with progressive cytomegalovirus (CMV)
disease due to a resistant CMV strain emerging under ganciclovir (GCV) therapy. A …

The emergence of cytomegalovirus resistance to ganciclovir therapy in kidney transplant recipients

E Nogueira, KS Ozaki, H Tomiyama… - International …, 2006 - Elsevier
Transplant recipients that have not been previously exposed to the cytomegalovirus (CMV)
are highly susceptible to viral diseases while under immunosuppression therapy. CMV …

Rapid detection directly from patient serum samples of human cytomegalovirus UL97 mutations conferring ganciclovir resistance

J Castor, L Cook, L Corey… - Journal of clinical …, 2007 - Am Soc Microbiol
Ganciclovir-resistant cytomegalovirus can cause disease and death in transplant recipients.
We describe here a rapid PCR-and sequencing-based assay for ganciclovir resistance that …

Dynamics of the emergence of a human cytomegalovirus UL97 mutant strain conferring ganciclovir resistance in a pediatric stem-cell transplant recipient

K Göhring, T Feuchtinger, E Mikeler, P Lang… - The Journal of Molecular …, 2009 - Elsevier
Stem-cell transplant recipients are at risk of developing ganciclovir-resistant human
cytomegalovirus (HCMV) infection caused by mutations in the viral UL97 gene. Knowledge …

Incidence and clinical features of ganciclovir-resistant cytomegalovirus disease in heart transplant recipients

F Li, KW Kenyon, KA Kirby, DP Fishbein… - Clinical infectious …, 2007 - academic.oup.com
Background. The incidence and clinical and virologic aspects of ganciclovir-resistant
cytomegalovirus (CMV) disease have not been well-characterized in heart transplant …