Astrocytes are involved in the neuroinflammation of neurodegenerative diseases, such as
Parkinson's disease (PD). Among the numerous inflammatory cytokines, interleukin-1β (IL …

Activated astrocytes secrete inflammatory cytokines such as interleukin-1β (IL-1β) into the
extracellular milieu, damaging surrounding neurons and involving in the pathogenesis of …

Inflammasomes are involved in diverse inflammatory diseases, so the activation of
inflammasomes needs to be tightly controlled to prevent excessive inflammation. However …

Abstract In the Central Nervous System (CNS), neuroinflammation orchestrated by microglia
and astrocytes is an innate immune response to counteract stressful and dangerous insults …

Background Inflammasomes are involved in diverse inflammatory diseases. Previous study
reported that the neurotransmitter dopamine inhibited NLRP3 inflammasome activation via …

Background Parkinson's disease (PD) is characterized by the loss of nigral dopaminergic
neurons leading to impaired striatal dopamine signaling, α-synuclein-(α-syn-) rich …

Background Parkinson's disease (PD) is characterized by degeneration of dopaminergic
neurons in the substantia nigra pars compacta (SNpc), accompanied by accumulation of α …

Background Parkinson's disease (PD) is a neurodegenerative disorder with progressive loss
of dopaminergic (DA) neurons. Systemic inflammation is shown to initiate and exacerbate …

The function and regulation of different heterogeneous reactive states of astrocytes in
depression remain unclear. Here, we demonstrate that neurotoxic reactive (A1-like) …

Background Neuroinflammation constitutes a pathogenic process leading to
neurodegeneration in several disorders, including Alzheimer's disease, Parkinson's disease …