Dopamine D2 receptor restricts astrocytic NLRP3 inflammasome activation via enhancing the interaction of β-arrestin2 and NLRP3
J Zhu, Z Hu, X Han, D Wang, Q Jiang, J Ding… - Cell Death & …, 2018 - nature.com
Astrocytes are involved in the neuroinflammation of neurodegenerative diseases, such as
Parkinson's disease (PD). Among the numerous inflammatory cytokines, interleukin-1β (IL …
Parkinson's disease (PD). Among the numerous inflammatory cytokines, interleukin-1β (IL …
Drd2 biased agonist prevents neurodegeneration against NLRP3 inflammasome in Parkinson's disease model via a β-arrestin2-biased mechanism
J Zhu, T Sun, J Zhang, Y Liu, D Wang, H Zhu… - Brain, Behavior, and …, 2020 - Elsevier
Activated astrocytes secrete inflammatory cytokines such as interleukin-1β (IL-1β) into the
extracellular milieu, damaging surrounding neurons and involving in the pathogenesis of …
extracellular milieu, damaging surrounding neurons and involving in the pathogenesis of …
Dopamine controls systemic inflammation through inhibition of NLRP3 inflammasome
Inflammasomes are involved in diverse inflammatory diseases, so the activation of
inflammasomes needs to be tightly controlled to prevent excessive inflammation. However …
inflammasomes needs to be tightly controlled to prevent excessive inflammation. However …
The role of dopamine in NLRP3 inflammasome inhibition: Implications for neurodegenerative diseases
Abstract In the Central Nervous System (CNS), neuroinflammation orchestrated by microglia
and astrocytes is an innate immune response to counteract stressful and dangerous insults …
and astrocytes is an innate immune response to counteract stressful and dangerous insults …
Activation of dopamine D1 receptor decreased NLRP3-mediated inflammation in intracerebral hemorrhage mice
T Wang, D Nowrangi, L Yu, T Lu, J Tang, B Han… - Journal of …, 2018 - Springer
Background Inflammasomes are involved in diverse inflammatory diseases. Previous study
reported that the neurotransmitter dopamine inhibited NLRP3 inflammasome activation via …
reported that the neurotransmitter dopamine inhibited NLRP3 inflammasome activation via …
Dopamine signaling modulates microglial NLRP3 inflammasome activation: implications for Parkinson's disease
AF Pike, F Longhena, G Faustini, JM Van Eik… - Journal of …, 2022 - Springer
Background Parkinson's disease (PD) is characterized by the loss of nigral dopaminergic
neurons leading to impaired striatal dopamine signaling, α-synuclein-(α-syn-) rich …
neurons leading to impaired striatal dopamine signaling, α-synuclein-(α-syn-) rich …
p38-TFEB pathways promote microglia activation through inhibiting CMA-mediated NLRP3 degradation in Parkinson's disease
J Chen, K Mao, H Yu, Y Wen, H She, H Zhang… - Journal of …, 2021 - Springer
Background Parkinson's disease (PD) is characterized by degeneration of dopaminergic
neurons in the substantia nigra pars compacta (SNpc), accompanied by accumulation of α …
neurons in the substantia nigra pars compacta (SNpc), accompanied by accumulation of α …
Inhibition of the hepatic Nlrp3 protects dopaminergic neurons via attenuating systemic inflammation in a MPTP/p mouse model of Parkinson's disease
Background Parkinson's disease (PD) is a neurodegenerative disorder with progressive loss
of dopaminergic (DA) neurons. Systemic inflammation is shown to initiate and exacerbate …
of dopaminergic (DA) neurons. Systemic inflammation is shown to initiate and exacerbate …
Microglial NLRP3 inflammasome activates neurotoxic astrocytes in depression-like mice
S Li, Y Fang, Y Zhang, M Song, X Zhang, X Ding… - Cell reports, 2022 - cell.com
The function and regulation of different heterogeneous reactive states of astrocytes in
depression remain unclear. Here, we demonstrate that neurotoxic reactive (A1-like) …
depression remain unclear. Here, we demonstrate that neurotoxic reactive (A1-like) …
Dopamine receptor D3 signalling in astrocytes promotes neuroinflammation
A Montoya, D Elgueta, J Campos, O Chovar… - Journal of …, 2019 - Springer
Background Neuroinflammation constitutes a pathogenic process leading to
neurodegeneration in several disorders, including Alzheimer's disease, Parkinson's disease …
neurodegeneration in several disorders, including Alzheimer's disease, Parkinson's disease …