Deletion of Trpm4 Alters the Function of the Nav1.5 Channel in Murine Cardiac Myocytes
LC Ozhathil, JS Rougier, P Arullampalam… - International journal of …, 2021 - mdpi.com
Transient receptor potential melastatin member 4 (TRPM4) encodes a Ca2+-activated, non-
selective cation channel that is functionally expressed in several tissues, including the heart …
selective cation channel that is functionally expressed in several tissues, including the heart …
Upregulation of transient receptor potential melastatin 4 (TRPM4) in ventricular fibroblasts from heart failure patients
The transient receptor potential melastatin 4 (TRPM4) is a Ca 2+-activated nonselective
monovalent cation channel belonging to the TRP channel superfamily. TRPM4 is widely …
monovalent cation channel belonging to the TRP channel superfamily. TRPM4 is widely …
Inherited cardiac arrhythmia syndromes: focus on molecular mechanisms underlying TRPM4 channelopathies
MY Amarouch, J El Hilaly - Cardiovascular Therapeutics, 2020 - Wiley Online Library
The Transient Receptor Potential Melastatin 4 (TRPM4) is a transmembrane N‐glycosylated
ion channel that belongs to the large family of TRP proteins. It has an equal permeability to …
ion channel that belongs to the large family of TRP proteins. It has an equal permeability to …
Four TRPM4 cation channel mutations found in cardiac conduction diseases lead to altered protein stability
B Bianchi, LC Ozhathil, A Medeiros-Domingo… - Frontiers in …, 2018 - frontiersin.org
Transient receptor potential melastatin member 4 (TRPM4), a non-selective cation channel,
mediates cell membrane depolarization in immune response, insulin secretion, neurological …
mediates cell membrane depolarization in immune response, insulin secretion, neurological …
TRPM4 channels in the cardiovascular system: physiology, pathophysiology, and pharmacology
H Abriel, N Syam, V Sottas, MY Amarouch… - Biochemical …, 2012 - Elsevier
The transient receptor potential channel (TRP) family comprises at least 28 genes in the
human genome. These channels are widely expressed in many different tissues, including …
human genome. These channels are widely expressed in many different tissues, including …
Variants of transient receptor potential melastatin member 4 in childhood atrioventricular block
N Syam, S Chatel, LC Ozhathil, V Sottas… - Journal of the …, 2016 - Am Heart Assoc
Background Transient receptor potential melastatin member 4 (TRPM 4) is a nonselective
cation channel. TRPM 4 mutations have been linked to cardiac conduction disease and …
cation channel. TRPM 4 mutations have been linked to cardiac conduction disease and …
Heterologously-expressed and liposome-reconstituted human transient receptor potential melastatin 4 channel (TRPM4) is a functional tetramer
M Constantine, CK Liew, V Lo, A Macmillan… - Scientific reports, 2016 - nature.com
Mutation, irregular expression and sustained activation of the Transient Receptor Potential
Channel, type Melastatin 4 (TRPM4), have been linked to various cardiovascular diseases …
Channel, type Melastatin 4 (TRPM4), have been linked to various cardiovascular diseases …
TRPM4 channels in the cardiovascular system
M Kruse, O Pongs - Current opinion in pharmacology, 2014 - Elsevier
Highlights•Mutations in the TRPM4 gene are associated with dysfunctions in the cardiac
conduction system.•At the molecular level mutations in TRPM4 lead to gain-of-channel …
conduction system.•At the molecular level mutations in TRPM4 lead to gain-of-channel …
Structure of full-length human TRPM4
Transient receptor potential melastatin subfamily member 4 (TRPM4) is a widely distributed,
calcium-activated, monovalent-selective cation channel. Mutations in human TRPM4 …
calcium-activated, monovalent-selective cation channel. Mutations in human TRPM4 …
Aberrant deactivation-induced gain of function in TRPM4 mutant is associated with human cardiac conduction block
A gain-of-function mutation in the Ca 2+-activated transient receptor potential melastatin
member 4 (TRPM4 A432T) is linked to life-threatening cardiac conduction disturbance, but …
member 4 (TRPM4 A432T) is linked to life-threatening cardiac conduction disturbance, but …