Animal studies have demonstrated that restoration of blood flow to severely ischemic
myocardium is a prerequisite for myocardial salvage. However, it has been shown that the …

Reperfusion, without doubt, is the most effective way to treat the ischaemic myocardium.
Late reperfusion may however cause further damage. Myocardial production of oxygen free …

Background: Myocardial ischemia–reperfusion represents a clinically relevant problem
associated with thrombolysis, angioplasty and coronary bypass surgery. Injury of …

In acute myocardial ischemia (AMI) the optimal treatment is rapid revascularization by
angioplasty or pharmacological thrombolysis. While this is essential to resuscitate the …

Reperfusion of acutely ischemic myocardium is associated with various distinctive
pathophysiologic derangements, which are collectively referred to as reperfusion injury …

Reperfusion, without doubt, is the most effective way to treat the ischaemic myocardium.
Late reperfusion may, however, cause further damage. We attempted to identify the nature …

The incidence and mortality of heart disease are the highest among all diseases all over the
world, and are still increasing with a world wide rise in living standards. To find effective …

Much evidence has accumulated implicating cytotoxic free radicals as an underlying
etiology of many clinical disorders. Prominent among these dis orders has been ischemic …

Over the last decade there has accmnulated considerable evidence that reactive oxygen
species (free radicals) are generated during ischaemia-reperfusion of the myocardimn, and …

Background: Several antioxidants have been found to have conflicting results in attenuating
myocardial reperfusion injury. These studies were done primarily in experimental protocols …