Angiotensin II contractile effects in mouse colon: role for pre‐ and post‐junctional AT1A receptors

M Mastropaolo, MG Zizzo, F Mulè, R Serio - Acta Physiologica, 2013 - Wiley Online Library
Aim This study investigates whether a local renin–angiotensin system (RAS) exists in mouse
colon and whether angiotensin II (Ang II) may play a role in the regulation of the contractile …

Activation of angiotensin II type 1 receptors and contractile activity in human sigmoid colon in vitro

M Mastropaolo, MG Zizzo, M Auteri… - Acta …, 2015 - Wiley Online Library
Aim To analyse the effects of angiotensin II (Ang II) on the contractility of human sigmoid
colon, and to characterize the subtype (s) of receptor (s) involved and the related action …

Angiotensin II type II receptors and colonic dysmotility in 2, 4‐dinitrofluorobenzenesulfonic acid‐induced colitis in rats

MG Zizzo, M Auteri, A Amato, G Caldara… - …, 2017 - Wiley Online Library
Abstract Background Angiotensin II (Ang II), the main peptide of the renin‐angiotensin
system (RAS), has been suggested to be involved in inflammatory bowel diseases. Since …

Angiotensin receptors and actions in guinea pig enteric nervous system

GD Wang, XY Wang, HZ Hu, XC Fang… - American Journal …, 2005 - journals.physiology.org
Actions of ANG II on electrical and synaptic behavior of enteric neurons in the guinea pig
small intestine were studied. Exposure to ANG II depolarized the membrane potential and …

Angiotensin II‐induced contractions in human jejunal wall musculature in vitro

E Spak, A Casselbrant, T Olbers, H Lönroth… - Acta …, 2008 - Wiley Online Library
Aim: Angiotensin II is well known for its contractile effects on smooth muscle cells. This effect
is also present in the gut previously shown in animal models. The aim of this study was to …

Interaction between the renin–angiotensin system and enteric neurotransmission contributes to colonic dysmotility in the TNBS-induced model of colitis

M Ferreira-Duarte, T Rodrigues-Pinto, T Sousa… - International Journal of …, 2021 - mdpi.com
Angiotensin II (Ang II) regulates colon contraction, acting not only directly on smooth muscle
but also indirectly, interfering with myenteric neuromodulation mediated by the activation of …

Angiotensin II induced contraction of rat and human small intestinal wall musculature in vitro

S Ewert, E Spak, T Olbers, E Johnsson… - Acta …, 2006 - Wiley Online Library
Abstract Background: Angiotensin II (Ang II) is a well‐known activator of smooth muscle in
the vasculature but has been little explored with regard to intestinal wall muscular activity …

Effects of antihypertensive agents on intestinal contractility in the spontaneously hypertensive rat: angiotensin receptor system downregulation by losartan

GS Patten, MY Abeywardena - Journal of Pharmacology and Experimental …, 2017 - ASPET
Hypertension is an inflammatory condition controlled by the renin angiotensin system and is
linked to kidney disease, diabetes mellitus, and recently to dysfunction of the gut. The aim of …

Animal model for angiotensin II effects in the internal anal sphincter smooth muscle: mechanism of action

YP Fan, RN Puri, S Rattan - American Journal of …, 2002 - journals.physiology.org
Effect of ANG II was investigated in in vitro smooth muscle strips and in isolated smooth
muscle cells (SMC). Among different species, rat internal and sphincter (IAS) smooth muscle …

Autoradiographic characterization of angiotensin II receptor subtypes in rat intestine

LA Sechi, JP Valentin, CA Griffin… - American Journal of …, 1993 - journals.physiology.org
Angiotensin II is known to regulate motility and ion and water absorption in the intestine.
These effects are presumed to be mediated by angiotensin II (ANG II) receptors that are …