Notch signaling in the cardiovascular system is important during embryonic development,
vascular repair of injury, and vascular pathology in humans. The vascular smooth muscle …

The Notch signaling pathway is critical for cell fate determination during embryonic
development, including many aspects of vascular development. An emerging paradigm …

Notch signaling is an ancient intercellular signaling mechanism that plays myriad roles
during vascular development and physiology in vertebrates. These roles include regulation …

The Notch signaling pathway is a highly conserved pathway involved in cell fate
determination in embryonic development and also functions in the regulation of …

It has become increasingly clear that the Notch signaling pathway plays a critical role in the
development and homeostasis of the cardiovascular system. This notion has emerged from …

Notch signaling is a key regulator of vascular smooth muscle cell (VSMC) phenotypes,
including differentiation, proliferation, and cell survival. However, the exact contribution of …

Notch signaling is an extremely conserved and widely used mechanism regulating cell fate
in metazoans. Interaction of Notch receptors (Notch) with their ligands (Delta-like or Jagged) …

The evolutionarily conserved Notch signaling pathway is required for normal vascular
development and function, and genetic associations link select Notch receptors and ligands …

An emerging hallmark of the Notch signaling pathway is its nearly ubiquitous participation in
cell fate decisions that affect several tissues, including epithelial, neuronal, hematopoietic …

Notch signaling has been implicated in the regulation of smooth muscle differentiation, but
the precise role of Notch receptors is ill defined. Although Notch3 receptor expression is …