BACKGROUND: The airway epithelium is the first line of defense against inhaled insults and
therefore must be capable of coordinating appropriate inflammatory and immune responses …

Exposure to particulate matter (PM), a major component of air pollution, contributes to
increased morbidity and mortality worldwide. Inhaled PM induces innate immune responses …

Little is known about innate immunity and components of inflammasomes in airway
epithelium. This study evaluated immunohistological evidence for NLRP3 inflammasomes in …

To cite this article: Besnard A‐G, Guillou N, Tschopp J, Erard F, Couillin I, Iwakura Y,
Quesniaux V, Ryffel B, Togbe D. NLRP3 inflammasome is required in murine asthma in the …

Inhaled allergens promote inflammatory response, tissue damage, and airway
hyperresponsiveness in the lungs, leading to allergic asthma. NLRP3, as an immune sensor …

Asthma is characterized by airway inflammation, airway hyperresponsiveness and airway
remodelling. Uncontrolled airway inflammation or repeated asthma exacerbations can lead …

Asthma is a heterogeneous inflammatory airways disorder where interleukin (IL)-1β is
thought to be a key mediator, especially in the neutrophilic subtype of asthma. The …

Background Cigarette smoke suppresses innate immunity, making smokers more
susceptible to infection. The NLRP3 inflammasome is a multi-protein complex that releases …

Activation of nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3)
inflammasome received substantial attention recently in inflammatory diseases …

Purpose: The airway epithelium represents the first line of defense against inhaled
environmental insults including air pollution, allergens, and viruses. Epidemiological and …