Overexpression of the Naturally Occurring blaOXA-51 Gene in Acinetobacter baumannii Mediated by Novel Insertion Sequence ISAba9

S Figueiredo, L Poirel, A Papa… - Antimicrobial agents …, 2009 - Am Soc Microbiol
Resistance to carbapenems in Acinetobacter baumannii is increasingly reported and is
mostly associated with expression of carbapenemases (3, 6). Those carbapenemases are …

OXA-235, a novel class D β-lactamase involved in resistance to carbapenems in Acinetobacter baumannii

PG Higgins, FJ Pérez-Llarena, E Zander… - Antimicrobial agents …, 2013 - Am Soc Microbiol
We investigated the mechanism of carbapenem resistance in 10 Acinetobacter baumannii
strains isolated from the United States and Mexico between 2005 and 2009. The detection of …

OXA-58, a Novel Class D β-Lactamase Involved in Resistance to Carbapenems in Acinetobacter baumannii

L Poirel, S Marqué, C Héritier, C Segonds… - Antimicrobial agents …, 2005 - Am Soc Microbiol
ABSTRACT A carbapenem-resistant Acinetobacter baumannii strain was isolated in
Toulouse, France, in 2003. Cloning and expression in Escherichia coli identified the …

Carbapenem-Resistant Acinetobacter baumannii Isolates Expressing the blaOXA-23 Gene Associated with ISAba4 in Belgium

P Bogaerts, G Cuzon, T Naas, C Bauraing… - Antimicrobial agents …, 2008 - Am Soc Microbiol
Carbapenems are among the drugs of choice for treating nosocomial infections due to
multidrug-resistant Acinetobacter baumannii strains (4). However, their efficacy is being …

Characterization of OXA-25, OXA-26, and OXA-27, molecular class D β-lactamases associated with carbapenem resistance in clinical isolates of Acinetobacter …

M Afzal-Shah, N Woodford… - Antimicrobial agents and …, 2001 - Am Soc Microbiol
Carbapenem resistance in Acinetobacter spp. is increasingly being associated with OXA-
type β-lactamases with weak hydrolytic activity against imipenem and meropenem. Such …

In Vivo Selection of Reduced Susceptibility to Carbapenems in Acinetobacter baumannii Related to ISAba1-Mediated Overexpression of the Natural blaOXA-66 …

S Figueiredo, L Poirel, J Croize, C Recule… - Antimicrobial agents …, 2009 - Am Soc Microbiol
Two clonally related Acinetobacter baumannii isolates, A1 and A2, were obtained from the
same patient. Isolate A2, selected after an imipenem-containing treatment, showed reduced …

Genetic Structures at the Origin of Acquisition and Expression of the Carbapenem-Hydrolyzing Oxacillinase Gene blaOXA-58 in Acinetobacter baumannii

L Poirel, P Nordmann - Antimicrobial agents and chemotherapy, 2006 - Am Soc Microbiol
Genetic structures surrounding the carbapenem-hydrolyzing oxacillinase gene bla OXA-58
were characterized in a series of OXA-58-positive Acinetobacter baumannii strains isolated …

Over-Expression of ISAba1-Linked Intrinsic and Exogenously Acquired OXA Type Carbapenem-Hydrolyzing-Class D-ß-Lactamase-Encoding Genes Is Key Mechanism …

MH Wong, BK Chan, EW Chan, S Chen - Frontiers in microbiology, 2019 - frontiersin.org
Acinetobacter baumannii is an important clinical pathogen which often causes fatal
infections among seriously ill patients. Treatment options for managing infections caused by …

Carbapenem-Resistant Acinetobacter baumannii Isolates from Tunisia Producing the OXA-58-Like Carbapenem-Hydrolyzing Oxacillinase OXA-97

L Poirel, W Mansour, O Bouallegue… - Antimicrobial agents …, 2008 - Am Soc Microbiol
The basis of the β-lactam resistance of 39 multidrug-resistant Acinetobacter baumannii
isolates recovered from hospitalized patients was studied. These isolates were collected …

Variability in carbapenemase activity of intrinsic OxaAb (OXA-51-like) β-lactamase enzymes in Acinetobacter baumannii

Y Takebayashi, J Findlay, KJ Heesom… - Journal of …, 2021 - academic.oup.com
Objectives To measure the variability in carbapenem susceptibility conferred by different
OxaAb variants, characterize the molecular evolution of oxaAb and elucidate the …