Enhanced and coordinated in vivo expression of inflammatory cytokines and nitric oxide synthase by chondrocytes from patients with osteoarthritis

C Melchiorri, R Meliconi, L Frizziero… - Arthritis & …, 1998 - Wiley Online Library
Objective To evaluate the sites of expression of interleukin‐1β (IL‐1β), tumor necrosis factor
α (TNFα), and inducible nitric oxide synthase (iNOS) in patients with inflammatory and …

[HTML][HTML] Molecular mechanisms of cartilage destruction: mechanics, inflammatory mediators, and aging collide

RF Loeser - Arthritis and rheumatism, 2006 - ncbi.nlm.nih.gov
Destruction and loss of articular cartilage is a central feature in most forms of arthritis
including the most common form, osteoarthritis (OA). The pathobiologic differences among …

Fundamentals of osteoarthritis: Inflammatory mediators in osteoarthritis

A De Roover, A Escribano-Núñez… - Osteoarthritis and …, 2023 - Elsevier
Objectives As more has become known of the pathophysiology of osteoarthritis (OA),
evidence that inflammation plays a critical role in its development and progression has …

Osteoarthritis: New insight on its pathophysiology

S Coaccioli, P Sarzi-Puttini, P Zis, G Rinonapoli… - Journal of Clinical …, 2022 - mdpi.com
Understanding of the basis of osteoarthritis (OA) has seen some interesting advancements
in recent years. It has been observed that cartilage degeneration is preceded by …

Therapeutics in osteoarthritis based on an understanding of its molecular pathogenesis

JR Kim, JJ Yoo, HA Kim - International journal of molecular sciences, 2018 - mdpi.com
Osteoarthritis (OA) is the most prevalent joint disease in older people and is characterized
by the progressive destruction of articular cartilage, synovial inflammation, changes in …

Osteoarthritis: a narrative review of molecular approaches to disease management

LA Salman, G Ahmed, SG Dakin, B Kendrick… - Arthritis Research & …, 2023 - Springer
Osteoarthritis (OA) is a chronic, progressive degenerative whole joint disease that affects the
articular cartilage, subchondral bone, ligaments, capsule, and synovium. While it is still …

Role of proinflammatory cytokines in the pathophysiology of osteoarthritis

M Kapoor, J Martel-Pelletier, D Lajeunesse… - Nature Reviews …, 2011 - nature.com
Osteoarthritis (OA) is associated with cartilage destruction, subchondral bone remodeling
and inflammation of the synovial membrane, although the etiology and pathogenesis …

The pathophysiology of osteoarthritis

F Iannone, G Lapadula - Aging clinical and experimental research, 2003 - Springer
Osteoarthritis (OA) is a complex disease whose pathogenesis includes the contribution of
biomechanical and metabolic factors which, altering the tissue homeostasis of articular …

Onset and progression of human osteoarthritis—Can growth factors, inflammatory cytokines, or differential miRNA expression concomitantly induce proliferation, ECM …

KA Boehme, B Rolauffs - International journal of molecular sciences, 2018 - mdpi.com
Osteoarthritis (OA) is a degenerative whole joint disease, for which no preventative or
therapeutic biological interventions are available. This is likely due to the fact that OA …

Most recent developments in strategies to reduce the progression of structural changes in osteoarthritis: today and tomorrow

JP Pelletier, J Martel-Pelletier, JP Raynauld - Arthritis research & therapy, 2006 - Springer
Osteoarthritis (OA), the most common of all arthritic conditions, is a social and financial
burden to all nations. The most recent research has significantly advanced our …