Myocardial dysfunction occurs prior to changes in ventricular geometry in mice with chronic kidney disease (CKD)

PD Winterberg, R Jiang, JT Maxwell… - Physiological …, 2016 - Wiley Online Library
Uremic cardiomyopathy is responsible for high morbidity and mortality rates among patients
with chronic kidney disease (CKD), but the underlying mechanisms contributing to this …

[HTML][HTML] A systematic review and meta-analysis of murine models of uremic cardiomyopathy

J Soppert, J Frisch, J Wirth, C Hemmers, P Boor… - Kidney international, 2022 - Elsevier
Chronic kidney disease (CKD) triggers the risk of developing uremic cardiomyopathy as
characterized by cardiac hypertrophy, fibrosis and functional impairment. Traditionally …

Subclinical abnormalities of left ventricular myocardial deformation in early-stage chronic kidney disease: the precursor of uremic cardiomyopathy?

NC Edwards, A Hirth, CJ Ferro, JN Townend… - Journal of the American …, 2008 - Elsevier
BACKGROUND: Abnormal left ventricular (LV) deformation is an independent predictor of
poor cardiovascular outcome in end-stage renal disease. Studies in early-stage chronic …

[HTML][HTML] Left ventricular hypertrophy in renal disease: beyond preload and afterload

E Ritz - Kidney international, 2009 - Elsevier
To explain ventricular concentric and/or eccentric hypertrophy in chronic kidney disease,
past studies suggested that this was the result of increased preload and/or afterload. Using a …

Mapping cardiac remodeling in chronic kidney disease

N Kaesler, M Cheng, J Nagai, J O'Sullivan… - Science …, 2023 - science.org
Patients with advanced chronic kidney disease (CKD) mostly die from sudden cardiac death
and recurrent heart failure. The mechanisms of cardiac remodeling are largely unclear. To …

Cardiac remodeling in rats with renal failure shows interventricular differences

J Švíglerová, J Kuncova, L Nalos… - Experimental …, 2012 - journals.sagepub.com
Chronic renal failure (CRF) is associated with an increased incidence of cardiovascular
diseases. Intensive research revealed a number of alterations in the heart during CRF; …

Experimental mild renal insufficiency mediates early cardiac apoptosis, fibrosis, and diastolic dysfunction: a kidney-heart connection

FL Martin, PM McKie, A Cataliotti… - American Journal …, 2012 - journals.physiology.org
Impaired renal function with loss of nephron number in chronic renal disease (CKD) is
associated with increased cardiovascular morbidity and mortality. However, the structural …

Cardiac metabolic remodelling in chronic kidney disease

N Patel, MM Yaqoob, D Aksentijevic - Nature Reviews Nephrology, 2022 - nature.com
Chronic kidney disease (CKD) affects millions of people globally and, for most patients, the
risk of developing cardiovascular disease is higher than that of progression to kidney failure …

Defining myocardial abnormalities across the stages of chronic kidney disease: a cardiac magnetic resonance imaging study

MK Hayer, A Radhakrishnan, AM Price, B Liu… - Cardiovascular …, 2020 - jacc.org
Objectives A proof of concept cross-sectional study investigating changes in myocardial
abnormalities across stages of chronic kidney disease (CKD). Characterizing noninvasive …

Pathological cardiac remodeling occurs early in CKD mice from unilateral urinary obstruction, and is attenuated by Enalapril

O Ham, W Jin, L Lei, HH Huang, K Tsuji, M Huang… - Scientific reports, 2018 - nature.com
Cardiovascular disease constitutes the leading cause of mortality in patients with chronic
kidney disease (CKD) and end-stage renal disease. Despite increasing recognition of a …