The antigen-major histocompatibility complex-T cell receptor interaction: a structural analysis
WV Williams, DB Weiner, S Wadsworth… - Immunologic …, 1988 - Springer
In summary, we wish to propose that regions on MHC molecules interact with
complementary regions on processed peptide antigens, and that the resultant Ag-MHC …
complementary regions on processed peptide antigens, and that the resultant Ag-MHC …
Simultaneous involvement of all six predicted antigen binding loops of the T cell receptor in recognition of the MHC/antigenic peptide complex.
S Kasibhatla, EA Nalefski, A Rao - Journal of immunology …, 1993 - journals.aai.org
The TCR is predicted to resemble the Fab fragment of an Ig molecule and by analogy to
possess six Ag binding loops that contact MHC proteins bound with antigenic peptides. We …
possess six Ag binding loops that contact MHC proteins bound with antigenic peptides. We …
[PDF][PDF] Structure, function, and diversity of class I major histocompatibility complex molecules
PJ Bjorkman, P Parham - Annual review of biochemistry, 1990 - authors.library.caltech.edu
TcRs, in common with the Ig receptors of B cells, are products of somatically rearranging
genes and are clonally expressed (reviewed in Refs. 1, 2 and MM Davis, this volume). There …
genes and are clonally expressed (reviewed in Refs. 1, 2 and MM Davis, this volume). There …
[引用][C] Structural Characteristics of Peptides Required for Their Interaction with IAd
T cells of the helper subset recognize antigen-derived peptides in association with major
histocompatibility complex (MHC) class I1 (Ia) molecules on the cell surface of antigen …
histocompatibility complex (MHC) class I1 (Ia) molecules on the cell surface of antigen …
Molecular components of T-cell recognition.
JL Jorgensen, PA Reay, EW Ehrich… - Annual review of …, 1992 - europepmc.org
We review recent data that increase our understanding of the ternary complex of the T cell
receptor (TCR), antigenic peptides, and molecules of the major histocompatibility complex …
receptor (TCR), antigenic peptides, and molecules of the major histocompatibility complex …
MHC-antigen interaction: what does the T cell receptor see?
P Kourilsky, JM Claverie - Advances in immunology, 1989 - Elsevier
Publisher Summary It was recognized that in most cases the antigen is processed by the
antigen-presenting cells (APC), such that the fragments of antigen, rather than antigen per …
antigen-presenting cells (APC), such that the fragments of antigen, rather than antigen per …
Model for the interaction of T-cell receptors with peptide/MHC complexes
PJ Bjorkman, MM Davis - Cold Spring Harbor Symposia on …, 1989 - symposium.cshlp.org
The immune response against a viral infection is mediated by two different types of cells
known as B and T lymphocytes. The receptor on the B cell is the wellcharacterized antibody …
known as B and T lymphocytes. The receptor on the B cell is the wellcharacterized antibody …
Inhibition of allorecognition by an H-2Kb-derived peptide is evidence for a T-cell binding region on a major histocompatibility complex molecule.
J Schneck, T Munitz, JE Coligan… - Proceedings of the …, 1989 - National Acad Sciences
The class I and class II major histocompatibility complex (MHC) antigens are polymorphic
cell-surface glycoproteins that present antigenic peptides to T lymphocytes in the generation …
cell-surface glycoproteins that present antigenic peptides to T lymphocytes in the generation …
On the molecular nature of⪡ restrictive⪢ antigenic elements present on major histocompatibility complex (MHC) proteins
J Novotny, RE Bruccoleri, P Kourilsky - Research in immunology, 1989 - Elsevier
By analogy with the way in which antibodies recognize their specific antigens, it appears
likely that T-cell receptors recognize peptides presented by MHC molecules as composite …
likely that T-cell receptors recognize peptides presented by MHC molecules as composite …
[引用][C] Biochemistry and distribution of the T cell receptor
C Hannum, J Freed, G Tarr, J Kappler… - Immunological …, 1984 - Wiley Online Library
We have been studying the properties of a protein, found exclusively on T cells, which
seems to be the molecule on these cells responsible for specific recognition of antigen (Ag) …
seems to be the molecule on these cells responsible for specific recognition of antigen (Ag) …