A2A adenosine receptors are highly expressed in the striatum where they modulate
dopaminergic activity. The role of A2A receptors in psychostimulant action is less well …

Repeated treatment with the psychostimulant amphetamine produces behavioral
sensitization that may represent the neural adaptations underlying some features of …

The function of striatal adenosine A 2A receptors (A 2A Rs) is well recognized because of
their high expression levels and the documented antagonistic interaction between A 2A Rs …

Abstract Adenosine A 2A receptors (A 2A Rs) are well positioned to influence the
maladaptive CNS responses to repeated dopaminergic stimulation in psychostimulant …

Adenosine A2A receptors (A2AR) are located postsynaptically in striatopallidal GABAergic
neurons, antagonizing dopamine D2 receptor functions, and are also located …

The A2AR is largely coexpressed with D2Rs and enkephalin mRNA in the striatum where it
modulates dopaminergic activity. Activation of the A2AR antagonizes D2R-mediated …

Adenosine receptors (AR) are a family of G-protein coupled receptors, comprised of four
members, named A 1, A 2A, A 2B, and A 3 receptors, found widely distributed in almost all …

We have examined behavioral consequences of genetic deletion of the adenosine A3
receptors in mice. The open field behavior of A3 adenosine receptor knock-out (A3R KO) …

The adenosine A 2A receptor is specifically enriched in the medium spiny neurons that
make up the 'indirect'output pathway from the ventral striatum, a structure known to have a …

Drug addiction is a serious brain disorder with somatic, psychological, psychiatric, socio-
economic and legal implications in the developed world. Illegal (eg, psychostimulants …