Until recently, monitoring of cerebral blood flow and metabolism was an unattained goal.
Determination of cerebral blood flow was limited to intermittent measurements and …

For optimal therapy of patients with brain injury, a thorough knowledge of the underlying
cerebral blood flow (CBF) physiology is essential. This chapter reviews the relationship …

Over 100years have passed since Adolf Fick [1) introduced in 1870the now wellestablished
principle that bears his name. Based on the conservation of mass, this principle simply …

This article addresses the rationale for the clinical measurement of cerebral blood flow
(CBF) in the neurosurgical intensive care unit (ICU). The techniques that are currently …

Publisher Summary This chapter discusses certain major aspects of the normal cerebral
circulation, its control, and its relationship to cerebral metabolism. It presents a brief …

Conventional management of patients following acute brain injury includes a 'primary goal'of
maintenance of an adequate cerebral perfusion pressure (CPP)[1, 2]. This is the pressure …

Cerebral physiologic monitoring techniques can be categorized into those measuring
perfusion, metabolism, and function. The physiologic basis for each of these is outlined, with …

The cerebral circulation has the same relation to the tissue which it perfuses as do blood
vessels in other vascular beds. Oxygen and substrate must be supplied in proportion to …

A comprehensive overview is presented on cerebral hemodynamics and metabolism in
intensive care, with emphasis on cerebral oxygenation monitoring and management. From …

During the last few years continuous measurements of CBF by means of a thermal diffusion
blood flow probe have been proposed as a possible means for monitoring the patient's CBF …