[PDF][PDF] Therapeutic approaches in inflammatory bowel disease based on the immunopathogenesis

B Siegmund, M Zeitz - Rocz Akad Med Bialymst, 2004 - Citeseer
Our understanding of the etiology and pathogenesis of IBD has improved extensively over
the past years. At the center of the pathogenesis seems to be an excessive proinflammatory …

Cytokines in the pathogenesis of inflammatory bowel diseases

J León, JA Garrote, E Arranz - Medicina Clinica, 2006 - europepmc.org
Inflammatory bowel disease (IBD) is produced by an exaggerated response to bacterial flora
within the intestinal mucous, in which both environmental and genetic factors are involved. T …

[HTML][HTML] Anti-TNF therapy and immunogenicity in inflammatory bowel diseases: a translational approach

LM Genaro, LEM Gomes… - American Journal of …, 2021 - ncbi.nlm.nih.gov
Inflammatory bowel diseases are chronic illnesses that involve intestinal inflammation and
are usually diagnosed as Crohn's disease or ulcerative colitis. As these diseases do not …

[HTML][HTML] Mucosal Immunology in the Inflammatory Bowel Diseases

GR Degasperi - Biological Therapy for Inflammatory Bowel …, 2019 - intechopen.com
Inflammatory bowel disease (IBD) includes two major phenotypes, Crohn's disease and
ulcerative colitis, which have different clinical characteristics and immune response profiles …

Immunology of inflammatory bowel diseases.

L Lakatos - Acta Physiologica Hungarica, 2000 - europepmc.org
The pathogenesis of inflammatory diseases involves complex interactions among genetic,
environmental and immunologic factors, where the immune system plays a crucial role. The …

[PDF][PDF] Update on the mechanisms of action of anti-TNF-α antibodies and their clinical implications in inflammatory bowel disease

P Eder, K Linke, J Witowski - Pol Arch Med Wewn, 2016 - researchgate.net
The mechanisms of action of antitumor necrosis factor α (anti-TNF-α) antibodies in the
therapy of inflammatory bowel disease (IBD) are not completely understood. Binding of …

The role and significance of the most important known cytokines in inflammatory bowel diseases

Z Vitalis, I Altorjay, M Udvardy - Orvosi Hetilap, 1998 - europepmc.org
Several theories have already been postulated in connection with the pathogenesis of
inflammatory bowel diseases, yet none of them has been approved. Recently increasing …

Efficacy of anti-TNF-alpha monoclonal antibodies in inflammatory bowel disease treatment

A Deleporte, S Viennot, B Dupont… - … Journal of Interferon …, 2013 - Taylor & Francis
Pathogenesis of inflammatory bowel disease (IBD), including Crohn's disease (CD) and
ulcerative colitis (UC), continues to drive basic research to better decrypt their causal factor …

[PDF][PDF] New insights into the cellular immunology of the intestine in relation to the pathophysiology of inflammatory bowel diseases

D Latinne, R Fiasse - Acta gastro-enterologica Belgica, 2006 - ageb.be
The authors review advances about altered immunological cellular mechanisms in
inflammatory bowel diseases (IBD). The innate immune response might play a role in the …

[HTML][HTML] Changes of the cytokine profile in inflammatory bowel diseases

G Műzes, B Molnár, Z Tulassay… - World journal of …, 2012 - ncbi.nlm.nih.gov
Cytokines are indispensable signals of the mucosa-associated immune system for
maintaining normal gut homeostasis. An imbalance of their profile in favour of inflammation …