The human immunodeficiency virus type 1 (HIV-1) integrase (IN) is a critical enzyme
involved in infection. It catalyzes two reactions to integrate the viral cDNA into the host …

Replication of HIV-1 requires the covalent integration of the viral cDNA into the host
chromosomal DNA directed by the virus-encoded integrase protein. Here we explore the …

Insolubility of full-length HIV-1 integrase (IN) limited previous structure analyses to individual
domains. By introducing five point mutations, we engineered a more soluble IN that allowed …

HIV integrase (IN) is an essential enzyme in HIV replication and an important target for drug
design. IN has been shown to interact with a number of cellular and viral proteins during the …

HIV-1 integrase (IN) is an essential enzyme for viral infection. Here, we report an extensive π
electron orbital interaction between four amino acids, W132, M178, F181 and F185, located …

HIV-1 integrase is an essential enzyme in the life cycle of the virus, responsible for
catalyzing the insertion of the viral genome into the host cell chromosome; it provides an …

To identify functional contacts between HIV-1 integrase (IN) and its viral DNA substrate, we
devised a new experimental strategy combining the following two methodologies. First …

Background: Integrase mediates a crucial step in the life cycle of the human
immunodeficiency virus (HIV). The enzyme cleaves the viral DNA ends in a sequence …

HIV-1 integrase (IN) mediates the insertion of viral cDNA into the cell genome, a vital
process for replication. This step is catalyzed by two separate DNA reaction events, termed …

Retroviral integrases are composed of three independently folding domains whose
organization relevant to one another is largely unknown. As an approach to understanding …