Oral cancer is an important global health problem. There is an urgent need for improved
methods to detect oral cancer and its precursors, because early detection is the best way to …

Accurately identifying close or positive margins in real‐time permits re‐excision during
surgical procedures. Intraoperative assessment of margins via gross examination and frozen …

Malignancies of the oral cavity are conventionally diagnosed by white light endoscopy,
biopsy, and histopathology. However, it is often difficult to distinguish between benign and …

Early detection of cancer is key to reducing morbidity and mortality. Morphological and
chemical biomarkers presage the transition from normal to cancerous tissue. We have …

A multispectral digital microscope (MDM) is designed and constructed as a tool to improve
detection of oral neoplasia. The MDM acquires in vivo images of oral tissue in fluorescence …

Recent developments in optical technologies have the potential to improve the speed and
accuracy of screening and diagnosis of curable precancerous lesions and early cancer …

A compact clinically compatible fluorescence lifetime imaging microscopy (FLIM) system
was designed and built for intraoperative disease diagnosis and validated in vivo in a …

Optical imaging and spectroscopy have emerged as effective tools for detecting malignant
changes associated with oral cancer. While clinical studies have demonstrated high …

Fluorescence-guided diagnosis of tumor tissue is in many cases insufficient, because false
positive results interfere with the outcome. Improvement through observation of cell …

Confocal endomicroscopy is a novel and non-invasive microscopic technique that enables
surface and subsurface imaging of living tissues or cells in vivo. The purpose of this study …