Growth retardation and altered autonomic control in mice lacking brain serotonin
Serotonin synthesis in mammals is initiated by 2 distinct tryptophan hydroxylases (TPH),
TPH1 and TPH2. By genetically ablating TPH2, we created mice (Tph2−/−) that lack …
TPH1 and TPH2. By genetically ablating TPH2, we created mice (Tph2−/−) that lack …
Genetic disruption of both tryptophan hydroxylase genes dramatically reduces serotonin and affects behavior in models sensitive to antidepressants
KV Savelieva, S Zhao, VM Pogorelov, I Rajan, Q Yang… - PloS one, 2008 - journals.plos.org
The neurotransmitter serotonin (5-HT) plays an important role in both the peripheral and
central nervous systems. The biosynthesis of serotonin is regulated by two rate-limiting …
central nervous systems. The biosynthesis of serotonin is regulated by two rate-limiting …
Life without brain serotonin: reevaluation of serotonin function with mice deficient in brain serotonin synthesis
V Mosienko, D Beis, M Pasqualetti, J Waider… - Behavioural brain …, 2015 - Elsevier
Tryptophan hydroxylase (TPH) is a rate limiting enzyme in the synthesis of serotonin (5-HT),
a monoamine which works as an autacoid in the periphery and as a neurotransmitter in the …
a monoamine which works as an autacoid in the periphery and as a neurotransmitter in the …
Disruption of the nonneuronal tph1 gene demonstrates the importance of peripheral serotonin in cardiac function
F Côté, E Thévenot, C Fligny… - Proceedings of the …, 2003 - National Acad Sciences
Serotonin (5-HT) controls a wide range of biological functions. In the brain, its implication as
a neurotransmitter and in the control of behavioral traits has been largely documented. At …
a neurotransmitter and in the control of behavioral traits has been largely documented. At …
Life without peripheral serotonin: insights from tryptophan hydroxylase 1 knockout mice reveal the existence of paracrine/autocrine serotonergic networks
P Amireault, D Sibon, F Côté - ACS chemical neuroscience, 2013 - ACS Publications
Since its identification, 75 years ago, the monoamine serotonin (5-HT) has attracted
considerable attention toward its role as a neurotransmitter in the central nervous system …
considerable attention toward its role as a neurotransmitter in the central nervous system …
Impacts of Brain Serotonin Deficiency following Tph2 Inactivation on Development and Raphe Neuron Serotonergic Specification
L Gutknecht, N Araragi, S Merker, J Waider… - 2012 - journals.plos.org
Brain serotonin (5-HT) is implicated in a wide range of functions from basic physiological
mechanisms to complex behaviors, including neuropsychiatric conditions, as well as in …
mechanisms to complex behaviors, including neuropsychiatric conditions, as well as in …
Late developmental stage-specific role of tryptophan hydroxylase 1 in brain serotonin levels
K Nakamura, Y Sugawara, K Sawabe… - Journal of …, 2006 - Soc Neuroscience
Serotonin [5-hydroxytryptamine (5-HT)] is a major therapeutic target of psychiatric disorders.
Tryptophan hydroxylase (TPH) catalyzes the rate-limiting reaction in the biosynthesis of 5 …
Tryptophan hydroxylase (TPH) catalyzes the rate-limiting reaction in the biosynthesis of 5 …
Spatio-temporal expression of tryptophan hydroxylase isoforms in murine and human brain: convergent data from Tph2 knockout mice
L Gutknecht, C Kriegebaum, J Waider, A Schmitt… - European …, 2009 - Elsevier
Dysregulation of tryptophan hydroxylase (TPH)-dependent serotonin (5-HT) synthesis, has
been implicated in various neuropsychiatric disorders, although the differential expression …
been implicated in various neuropsychiatric disorders, although the differential expression …
Deficient serotonin neurotransmission and depression-like serotonin biomarker alterations in tryptophan hydroxylase 2 (Tph2) loss-of-function mice
JPR Jacobsen, WB Siesser, BD Sachs, S Peterson… - Molecular …, 2012 - nature.com
Probably the foremost hypothesis of depression is the 5-hydroxytryptamine (5-HT, serotonin)
deficiency hypothesis. Accordingly, anomalies in putative 5-HT biomarkers have repeatedly …
deficiency hypothesis. Accordingly, anomalies in putative 5-HT biomarkers have repeatedly …
Tryptophan hydroxylase-2 controls brain serotonin synthesis
Dysregulation of brain serotonin contributes to many psychiatric disorders. Tryptophan
hydroxylase-2 (Tph2), rather than Tph1, is preferentially expressed in the brain. We report a …
hydroxylase-2 (Tph2), rather than Tph1, is preferentially expressed in the brain. We report a …