Aims To examine diurnal variation in biliary excretion of flomoxef. Methods Flomoxef (1 g)
was injected intravenously in eight patients with percutaneous transhepatic …

We previously reported that the biliary excretion of flomoxef, an oxacephem antibiotic, was
greater after dosing at 21: 00 than at 09: 00h in diurnally active human subjects. The present …

Objective Cardiopulmonary bypass (CPB) induces changes in the pharmacokinetics of
drugs. The purpose of this study was to model the pharmacokinetics of flomoxef, a …

The purpose of this study was to investigate the population pharmacokinetics of prophylactic
flomoxef based on serum and liver tissue concentrations and to demonstrate a …

The pharmacokinetics of flosequinan and its active metabolite, flosequinoxan, were
investigated following a single 100mg oral dose in 10 patients with compromised hepatic …

We describe a 69-year-old male patient with the status of obstructive jaundice post
percutaneous biliary drainage for prior obstructive jaundice and who presented with a …

Background & Aims Patients with primary biliary cholangitis (PBC) who have an incomplete
response to ursodeoxycholic acid remain at risk of disease progression. We investigated the …

Background In primary bile acid diarrhoea, feedback by farnesoid X receptor (FXR) and
fibroblast growth hormone 19 (FGF19) on hepatic bile acid production is impaired. Aims To …

The pharmacokinetics of fluvoxamine maleate were investigated in 13 patients with biopsy-
proven liver cirrhosis. They received a single oral 100mg dose as an enteric-coated tablet …

Background: Biliary secretion of antibiotic agents into the bile is considerably compromised
by biliary obstruction, a precondition of bacterial cholangitis. Moxifloxacin may be …