[HTML][HTML] Loss of WTAP impairs early parthenogenetic embryo development

J Hao, S Huang, D Wang, Y Jin, M Zhang, J Zhang… - Animals, 2021 - mdpi.com
Simple Summary Wilms' tumor 1-associating protein (WTAP) is a key subunit of the N6-
methyl-adenosine (m6A) methyltransferase complex during porcine early embryo …

[HTML][HTML] Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase

XL Ping, BF Sun, LU Wang, W Xiao, X Yang, WJ Wang… - Cell research, 2014 - nature.com
Abstract The methyltransferase like 3 (METTL3)-containing methyltransferase complex
catalyzes the N6-methyladenosine (m6A) formation, a novel epitranscriptomic marker; …

[HTML][HTML] Role of WTAP in cancer: from mechanisms to the therapeutic potential

Y Fan, X Li, H Sun, Z Gao, Z Zhu, K Yuan - Biomolecules, 2022 - mdpi.com
Wilms' tumor 1-associating protein (WTAP) is required for N6-methyladenosine (m6A) RNA
methylation modifications, which regulate biological processes such as RNA splicing, cell …

[HTML][HTML] The RNA m6A writer WTAP in diseases: structure, roles, and mechanisms

Q Huang, J Mo, Z Liao, X Chen, B Zhang - Cell Death & Disease, 2022 - nature.com
Abstract N6-methyladenosine (m6A) is a widely investigated RNA modification in studies on
the “epigenetic regulation” of mRNAs that is ubiquitously present in eukaryotes. Abnormal …

[HTML][HTML] METTL3 regulates WTAP protein homeostasis

M Sorci, Z Ianniello, S Cruciani, S Larivera… - Cell death & …, 2018 - nature.com
Abstract The Wilms tumor 1 (WT1)-associated protein (WTAP) is upregulated in many
tumors, including, acute myeloid leukemia (AML), where it plays an oncogenic role by …

[HTML][HTML] N6-methyladenosine (m6A) RNA methylation mediated by methyltransferase complex subunit WTAP regulates amelogenesis

F Xie, X Zhu, X Liu, H Chen, J Wang - Journal of Biological Chemistry, 2022 - ASBMB
N6-methyladenosine (m6A) RNA methylation, one of the most widespread
posttranscriptional modifications in eukaryotes, plays crucial roles in various developmental …

Dynamic reprogramming and function of RNA N6-methyladenosine modification during porcine early embryonic development

T Yu, X Qi, L Zhang, W Ning, D Gao, T Xu, Y Ma… - Zygote, 2021 - cambridge.org
N6-Methyladenosine (m6A) regulates oocyte-to-embryo transition and the reprogramming of
somatic cells into induced pluripotent stem cells. However, the role of m6A methylation in …

Mettl14 is required for mouse post-implantation development by facilitating epiblast maturation

TG Meng, X Lu, L Guo, GM Hou, XS Ma, QN Li… - bioRxiv, 2018 - biorxiv.org
ABSTRACT N6-methyladenosine (m6A) is the most prevalent and reversible internal
modification of mammalian messenger and noncoding RNAs mediated by specific m6A …

[HTML][HTML] Arginine methylation of METTL14 promotes RNA N6-methyladenosine modification and endoderm differentiation of mouse embryonic stem cells

X Liu, H Wang, X Zhao, Q Luo, Q Wang, K Tan… - Nature …, 2021 - nature.com
Abstract RNA N 6-methyladenosine (m6A), the most abundant internal modification of
mRNAs, plays key roles in human development and health. Post-translational methylation of …

METTL3 regulates m6A in endometrioid epithelial ovarian cancer independently of METTl14 and WTAP

Z Ma, Q Li, P Liu, W Dong, Y Zuo - Cell Biology International, 2020 - Wiley Online Library
Abstract N6‐methyladenosine (m6A) RNA methylation, one of the common RNA
modifications, has been determined to execute crucial functions in tumorigenesis and …