The RNA m6A writer METTL14 in cancers: Roles, structures, and applications
H Zhou, K Yin, Y Zhang, J Tian, S Wang - Biochimica et Biophysica Acta …, 2021 - Elsevier
Abstract N 6-methyladenosine (m 6 A) is the most abundant and diverse epigenetic
modification of mRNAs in eukaryotes, and it regulates biological metabolism, cell …
modification of mRNAs in eukaryotes, and it regulates biological metabolism, cell …
METTL3-mediated m6A methylation negatively modulates autophagy to support porcine blastocyst development
Z Cao, L Zhang, R Hong, Y Li, Y Wang… - Biology of …, 2021 - academic.oup.com
Abstract N6-methyladenosine (m6A) catalyzed by METTL3 regulates the maternal-to-zygotic
transition in zebrafish and mice. However, the role and mechanism of METTL3-mediated …
transition in zebrafish and mice. However, the role and mechanism of METTL3-mediated …
Deficiency in a glutamine-specific methyltransferase for release factor causes mouse embryonic lethality
Biological methylation is a fundamental enzymatic reaction for a variety of substrates in
multiple cellular processes. Mammalian N6amt1 was thought to be a homologue of bacterial …
multiple cellular processes. Mammalian N6amt1 was thought to be a homologue of bacterial …
[HTML][HTML] PRMT1 methylates METTL14 to modulate its oncogenic function
Abstract N6-methyladenosine (m6A), the most abundant mRNA modification in mammalian
cells, is responsible for mRNA stability and alternative splicing. The METTL3-METTL14 …
cells, is responsible for mRNA stability and alternative splicing. The METTL3-METTL14 …
The emerging, multifaceted role of WTAP in Cancer and Cancer Therapeutics
G Ju, J Lei, S Cai, S Liu, X Yin, C Peng - Cancers, 2023 - mdpi.com
Simple Summary N6-methyladenosine (m6A) modification is among the most common and
conservative RNA modifications in eukaryotes. The deposition of m6A on RNA is carried out …
conservative RNA modifications in eukaryotes. The deposition of m6A on RNA is carried out …
WTAP–VIRMA counteracts dsDNA binding of the m6A writer METTL3–METTL14 complex and maintains N6-adenosine methylation activity
X Yan, F Liu, J Yan, M Hou, M Sun, D Zhang, Z Gong… - Cell Discovery, 2023 - nature.com
Dear Editor, N6-methyladenosine (m6A) is a prevalent epigenetic modification found in
eukaryotic mRNA and plays a crucial role in regulating gene expression in various …
eukaryotic mRNA and plays a crucial role in regulating gene expression in various …
The 18S rRNA m6A methyltransferase METTL5 promotes mouse embryonic stem cell differentiation
RNA modifications represent a novel layer of regulation of gene expression. Functional
experiments revealed that N6‐methyladenosine (m6A) on messenger RNA (mRNA) plays …
experiments revealed that N6‐methyladenosine (m6A) on messenger RNA (mRNA) plays …
Role of N6-methyl-adenosine modification in mammalian embryonic development
C Li, Z Jiang, J Hao, D Liu, H Hu, Y Gao… - Genetics and Molecular …, 2021 - SciELO Brasil
Abstract N6-methyl-adenosine (m6A) methylation is one of the most common and abundant
modifications of RNA molecules in eukaryotes. Although various biological roles of m6A …
modifications of RNA molecules in eukaryotes. Although various biological roles of m6A …
Zc3h13 regulates nuclear RNA m6A methylation and mouse embryonic stem cell self-renewal
Summary N 6-methyladenosine (m 6 A) is an abundant modification in eukaryotic mRNA,
regulating mRNA dynamics by influencing mRNA stability, splicing, export, and translation …
regulating mRNA dynamics by influencing mRNA stability, splicing, export, and translation …
METTL3 stabilization by PIN1 promotes breast tumorigenesis via enhanced m6A-dependent translation
PY Bhattarai, G Kim, SC Lim, R Mariappan, T Ohn… - Oncogene, 2023 - nature.com
Abstract Methyltransferase-like 3 (METTL3) is the catalytic subunit of the N 6-adenosine
methyltransferase complex responsible for N 6-methyladenosine (m6A) modification of …
methyltransferase complex responsible for N 6-methyladenosine (m6A) modification of …