METTL16 promotes osteosarcoma progression by downregulating VPS33B in an m6A‐dependent manner

J Cheng, Z Xu, W Tan, J He, B Pan… - Journal of Cellular …, 2024 - Wiley Online Library
Abstract N6‐methyladenosine (m6A) is one of the main epitranscriptomic modifications that
accelerates the progression of malignant tumors by modifying RNA. Methyltransferase‐like …

[PDF][PDF] N6-methyladenosine modification of MALAT1 promotes metastasis via reshaping nuclear speckles

X Wang, C Liu, S Zhang, H Yan, L Zhang, A Jiang… - Developmental cell, 2021 - cell.com
Summary N6-methyladenosine (m 6 A), one of the most prevalent RNA post-transcriptional
modifications, is involved in numerous biological processes. In previous studies, the …

METTL3 preferentially enhances non-m6A translation of epigenetic factors and promotes tumourigenesis

X Wei, Y Huo, J Pi, Y Gao, S Rao, M He, Q Wei… - Nature Cell …, 2022 - nature.com
METTL3 encodes the predominant catalytic enzyme to promote m6A methylation in nucleus.
Recently, accumulating evidence has shown the expression of METTL3 in cytoplasm, but its …

[HTML][HTML] The potential roles of RNA N6-methyladenosine in urological tumors

Y Li, Y Ge, L Xu, Z Xu, Q Dou, R Jia - Frontiers in Cell and …, 2020 - frontiersin.org
N6-methyladenosine (m6A) is regarded as the most abundant, prevalent and conserved
internal mRNA modification in mammalian cells. M6A can be catalyzed by m6A …

Histone methyltransferase SETD2 is required for porcine early embryonic development

W Shao, W Ning, C Liu, Y Zou, Y Yao, J Kang, Z Cao - Animals, 2022 - mdpi.com
Simple Summary Normal early embryonic development is important for ensuring sow fertility.
Low quality of in vitro production embryos severely limits extensive application of porcine …

METTL3 protects METTL14 from STUB1‐mediated degradation to maintain m6A homeostasis

ZC Zeng, Q Pan, YM Sun, HJ Huang, XT Chen… - EMBO …, 2023 - embopress.org
Abstract N 6‐Methyladenosine (m6A) is an important RNA modification catalyzed by
methyltransferase‐like 3 (METTL3) and METTL14. m6A homeostasis mediated by the …

Epigenetic regulation of mRNA N6-methyladenosine modifications in mammalian gametogenesis

F Fang, X Wang, Z Li, K Ni… - Molecular Human …, 2021 - academic.oup.com
Abstract N6-methyladenosine (m6A) is the most prevalent epigenetic modification of mRNAs
and broadly influences various biological processes by regulating post-transcriptional gene …

METTL14 is a chromatin regulator independent of its RNA N6-methyladenosine methyltransferase activity

X Dou, L Huang, Y Xiao, C Liu, Y Li, X Zhang… - Protein & …, 2023 - academic.oup.com
METTL3 and METTL14 are two components that form the core heterodimer of the main RNA
m6A methyltransferase complex (MTC) that installs m6A. Surprisingly, depletion of METTL3 …

WTAP promotes osteosarcoma tumorigenesis by repressing HMBOX1 expression in an m6A-dependent manner

S Chen, Y Li, S Zhi, Z Ding, W Wang, YI Peng… - Cell death & …, 2020 - nature.com
Abstract N6-methyladenosine (m6A) regulators are involved in the progression of various
cancers via regulating m6A modification. However, the potential role and mechanism of the …

RNA N6-methyladenosine methylation in post-transcriptional gene expression regulation

Y Yue, J Liu, C He - Genes & development, 2015 - genesdev.cshlp.org
N 6-methyladenosine (m6A) is the most prevalent and internal modification that occurs in the
messenger RNAs (mRNA) of most eukaryotes, although its functional relevance remained a …