Goal-oriented searching mediated by ventral hippocampus early in trial-and-error learning

S Ruediger, D Spirig, F Donato, P Caroni - Nature neuroscience, 2012 - nature.com
Most behavioral learning in biology is trial and error, but how these learning processes are
influenced by individual brain systems is poorly understood. Here we show that ventral-to …

Hippocampal brain-network coordination during volitional exploratory behavior enhances learning

JL Voss, BD Gonsalves, KD Federmeier, D Tranel… - Nature …, 2011 - nature.com
Exploratory behaviors during learning determine what is studied and when, helping to
optimize subsequent memory performance. To elucidate the cognitive and neural …

The ventral hippocampus is involved in multi‐goal obstacle‐rich spatial navigation

M Contreras, T Pelc, M Llofriu, A Weitzenfeld… - …, 2018 - Wiley Online Library
A large body of evidence shows that the hippocampus is necessary for successful spatial
navigation. Various studies have shown anatomical and functional differences between the …

Hippocampal place-cell sequences depict future paths to remembered goals

BE Pfeiffer, DJ Foster - Nature, 2013 - nature.com
Effective navigation requires planning extended routes to remembered goal locations.
Hippocampal place cells have been proposed to have a role in navigational planning, but …

Spatial learning drives rapid goal representation in hippocampal ripples without place field accumulation or goal-oriented theta sequences

BE Pfeiffer - Journal of Neuroscience, 2022 - Soc Neuroscience
The hippocampus is critical for rapid acquisition of many forms of memory, although the
circuit-level mechanisms through which the hippocampus rapidly consolidates novel …

Hippocampal neural activity reflects the economy of choices during goal‐directed navigation

VL Tryon, MR Penner, SW Heide, HO King… - …, 2017 - Wiley Online Library
Distinguishing spatial contexts is likely essential for the well‐known role of the hippocampus
in episodic memory. We studied whether types of hippocampal neural organization thought …

Distinct hippocampal versus frontoparietal network contributions to retrieval and memory-guided exploration

DJ Bridge, NJ Cohen, JL Voss - Journal of cognitive neuroscience, 2017 - direct.mit.edu
Memory can profoundly influence new learning, presumably because memory optimizes
exploration of to-be-learned material. Although hippocampus and frontoparietal networks …

Impaired spatial selectivity and intact phase precession in two-dimensional virtual reality

ZM Aghajan, L Acharya, JJ Moore, JD Cushman… - Nature …, 2015 - nature.com
During real-world (RW) exploration, rodent hippocampal activity shows robust spatial
selectivity, which is hypothesized to be governed largely by distal visual cues, although …

Hippocampal lesions disrupt navigation based on cognitive maps but not heading vectors

JM Pearce, ADL Roberts, M Good - Nature, 1998 - nature.com
Animals can find a hidden goal in several ways. They might use a cognitive map that
encodes information about the geometric relationship between the goal and two or more …

A prefrontal–thalamo–hippocampal circuit for goal-directed spatial navigation

HT Ito, SJ Zhang, MP Witter, EI Moser, MB Moser - Nature, 2015 - nature.com
Spatial navigation requires information about the relationship between current and future
positions. The activity of hippocampal neurons appears to reflect such a relationship …