Intra‐articular injection of human synovial membrane‐derived mesenchymal stem cells in murine collagen‐induced arthritis: assessment of immunomodulatory …

M Yan, X Liu, Q Dang, H Huang, F Yang… - Stem cells …, 2017 - Wiley Online Library
The aim of this study was to evaluate the efficacy of human synovial membrane‐derived
MSCs (SM‐MSCs) in murine collagen‐induced arthritis (CIA). Male mice (age 7–9 weeks) …

[HTML][HTML] Intraperitoneal infusion of mesenchymal stem cell attenuates severity of collagen antibody induced arthritis

Y Nam, SM Jung, YA Rim, H Jung, K Lee, N Park… - PLoS …, 2018 - journals.plos.org
It is unclear how systemic administration of mesenchymal stem cells (MSCs) controls local
inflammation. The aim of this study was to evaluate the therapeutic effects of human MSCs …

Immunosuppressive effects of mesenchymal stem cells in collagen-induced mouse arthritis

F Mao, WR Xu, H Qian, W Zhu, YM Yan, QX Shao… - Inflammation …, 2010 - Springer
Objective The objective of this study was to investigate the efficacy of mesenchymal stem
cell (MSC) in the treatment of arthritis. Methods Mesenchymal stem cells were injected …

Treatment of collagen-induced arthritis using immune modulatory properties of human mesenchymal stem cells

KH Park, CH Mun, MI Kang, SW Lee… - Cell …, 2016 - journals.sagepub.com
Mesenchymal stem cells (MSCs) have immune modulatory properties. We investigated the
potential therapeutic effects of human bone marrow (BM)-, adipose tissue (AD)-, and cord …

[HTML][HTML] Intra-articular injection of mesenchymal stem cells leads to reduced inflammation and cartilage damage in murine antigen-induced arthritis

O Kehoe, A Cartwright, A Askari, AJ El Haj… - Journal of translational …, 2014 - Springer
Background Rheumatoid arthritis (RA) is a debilitating and painful disease leading to
increased morbidity and mortality and novel therapeutic approaches are needed. The …

[HTML][HTML] Mesenchymal stem cell-conditioned medium reduces disease severity and immune responses in inflammatory arthritis

AG Kay, G Long, G Tyler, A Stefan, SJ Broadfoot… - Scientific reports, 2017 - nature.com
We evaluated the therapeutic potential of mesenchymal stem cell-conditioned medium (CM-
MSC) as an alternative to cell therapy in an antigen-induced model of arthritis (AIA). Disease …

Cell therapy using allogeneic bone marrow mesenchymal stem cells prevents tissue damage in collagen‐induced arthritis

A Augello, R Tasso, SM Negrini… - Arthritis & …, 2007 - Wiley Online Library
Abstract Objective Mesenchymal stem cells (MSCs) are precursors of tissue of mesenchymal
origin, but they also have the capacity to regulate the immune response by suppressing T …

Reversal of the immunosuppressive properties of mesenchymal stem cells by tumor necrosis factor α in collagen‐induced arthritis

F Djouad, V Fritz, F Apparailly… - Arthritis & …, 2005 - Wiley Online Library
Objective Adult mesenchymal stem cells (MSCs) represent promising tools for therapeutic
applications such as tissue engineering and cellular therapy. Recent data suggest that, due …

Mesenchymal stromal cells from osteoarthritic synovium are a distinct population compared to their bone‐marrow counterparts regarding surface marker distribution …

S Hagmann, C Rimmele, F Bucur… - Stem Cells …, 2016 - Wiley Online Library
Introduction. The participation of an inflammatory joint milieu has been described in
osteoarthritis (OA) pathogenesis. Mesenchymal stromal cells (MSCs) play an important role …

Immunomodulatory properties of mesenchymal stem cell in experimental arthritis in rat and mouse models: A systematic review

K Hynes, R Bright, S Proudman, D Haynes… - Seminars in Arthritis and …, 2016 - Elsevier
Background Despite recent advances in the treatment of arthritis with the development of
disease-modifying antirheumatic drugs, 30% of patients still fail to respond to treatment …