When mummy and daddy get under your skin: A new look at how parenting affects children's DNA methylation, stress reactivity, and disruptive behavior

G Overbeek, N Creasey, C Wesarg… - New directions for …, 2020 - Wiley Online Library
Child maltreatment is a global phenomenon that affects the lives of millions of children.
Worldwide, as many as one in three to six children encounter physical, sexual, or emotional …

DNA methylation: a mediator between parenting stress and adverse child development?

RH Mulder, J Rijlaarsdam… - Parental stress and early …, 2017 - Springer
In this chapter, we provide an overview of empirical studies evaluating the role of
epigenetics in mediating the association between parenting stress and adverse child …

DNA methylation of NR3c1 in infancy: Associations between maternal caregiving and infant sex

E Conradt, B Ostlund, D Guerin… - Infant Mental Health …, 2019 - Wiley Online Library
Caregivers play a critical role in scaffolding infant stress reactivity and regulation, but the
mechanisms by which this scaffolding occurs is unclear. Animal models strongly suggest …

Maternal attachment insecurity, maltreatment history, and depressive symptoms are associated with broad DNA methylation signatures in infants

TK Robakis, MC Roth, LS King, KL Humphreys… - Molecular …, 2022 - nature.com
The early environment, including maternal characteristics, provides many cues to young
organisms that shape their long-term physical and mental health. Identifying the earliest …

Methylation of exons 1D, 1F, and 1H of the glucocorticoid receptor gene promoter and exposure to adversity in preschool-aged children

AR Tyrka, SH Parade, NM Eslinger… - Development and …, 2015 - cambridge.org
Epigenetic modifications to the genome are a key mechanism involved in the biological
encoding of experience. Animal studies and a growing body of literature in humans have …

Dynamic stress-related epigenetic regulation of the glucocorticoid receptor gene promoter during early development: The role of child maltreatment

J Parent, SH Parade, LE Laumann… - Development and …, 2017 - cambridge.org
Epigenetics processes may play a vital role in the biological embedding of early
environmental adversity and the development of psychopathology. Accumulating evidence …

Epigenetics and child abuse: Modern‐day Darwinism—The miraculous ability of the human genome to adapt, and then adapt again

NB Gershon, PC High - … Journal of Medical Genetics Part C …, 2015 - Wiley Online Library
It has long been recognized that early adversity can have life‐long consequences, and the
extent to which this is true is gaining increasing attention. A growing body of literature …

Children's biobehavioral reactivity to challenge predicts DNA methylation in adolescence and emerging adulthood

SJ Goodman, DS Roubinov, NR Bush… - Developmental …, 2019 - Wiley Online Library
A growing body of research has documented associations between adverse childhood
environments and DNA methylation, highlighting epigenetic processes as potential …

Epigenetic programming by maternal behavior in the human infant

BM Lester, E Conradt, LL LaGasse, EZ Tronick… - …, 2018 - publications.aap.org
OBJECTIVES: We sought to determine if variations in maternal care alter DNA methylation in
term, healthy, 5-month-old infants. This work was based on landmark studies in animal …

Childhood maltreatment and stress-related psychopathology: the epigenetic memory hypothesis

PE Lutz, D Almeida, LM Fiori… - Current pharmaceutical …, 2015 - ingentaconnect.com
Childhood maltreatment (CM) is all too frequent among western societies, with an estimated
prevalence of 10 to 15%. CM associates with increased risk of several psychiatric disorders …