Mycobacterium tuberculosis is an enormously successful human pathogen that can infect its
host for decades without causing clinical disease, only to reactivate when host immunity is …

The granuloma is the defining feature of the host response to infection with Mycobacterium
tuberculosis (Mtb). Despite knowing of its existence for centuries, much remains unclear …

The granuloma that forms in response to Mycobacterium tuberculosis must be carefully
balanced in terms of immune responses to provide sufficient immune cell activation to inhibit …

▪ Abstract Pathogenic mycobacteria, including the causative agents of tuberculosis and
leprosy, are responsible for considerable morbidity and mortality worldwide. A hallmark of …

A granuloma is defined as an inflammatory mononuclear cell infiltrate that, while capable of
limiting growth of Mycobacterium tuberculosis, also provides a survival niche from which the …

Mycobacterium tuberculosis, the causative agent of tuberculosis, has infected humans for
millennia. M. tuberculosis is well adapted to establish infection, persist in the face of the host …

Infection with Mycobacterium tuberculosis causes> 1.5 million deaths worldwide annually.
Innate immune cells are the first to encounter M. tuberculosis, and their response dictates …

Mycobacterium tuberculosis is a highly efficient pathogen, killing millions of infected people
annually. The capacity of M. tuberculosis to survive and cause disease is strongly correlated …

The intimate and persistent connection between Mycobacterium tuberculosis and its human
host suggests that the pathogen has evolved extensive mechanisms to evade eradication by …

The central pathogen-immune interface in tuberculosis is the granuloma, a complex host
immune structure that dictates infection trajectory and physiology. Granuloma macrophages …