In utero hematopoietic stem cell transplantation (IUHSCTx) can achieve mixed
hematopoietic chimerism and donor-specific tolerance without cytoreductive conditioning or …

OBJECTIVE: In utero hematopoietic cell transplantation (IUHCT) typically achieves low-level
mixed hematopoietic chimerism. However, the goal of IUHCT is to achieve therapeutic levels …

Evidence supporting the efficacy of in utero hematopoietic cell transplantation (IUHCT) in a
valid large animal model is needed prior to clinical application. The objective of this study …

Successful in utero hematopoietic stem cell transplantation will likely represent a major step
forward in the management of patients with congenital hematological, metabolic, and …

OBJECTIVE: In the absence of immunodeficiency, only microchimerism (< 0.1%) has been
achieved in human fetal recipients or nonhuman primates following in utero hematopoietic …

Clinical application of allogeneic bone marrow transplantation (BMT) has been limited by
toxicity related to cytoreductive conditioning and immune response. In utero hematopoietic …

Stable engraftment of hematopoietic progenitors and multilineage chimerism following in
utero bone marrow transplantation could be a promising modality for treatment of prenatally …

In the murine model, in utero hematopoietic cell transplantation (IUHCT) has been shown to
achieve low levels of allogeneic chimerism and associated donor-specific tolerance …

OBJECTIVE: Our purpose was to create xenogeneic lymphohematopoietic chimerism by in
utero transplantation of human fetal liver cells in the midgestation fetal baboon. STUDY …

Bone marrow transplantation to reconstitute defective hematopoietic cell lines in children
with congenital defects is limited by donor availability, graft rejection, and graft-versus-host …